Choriodecidual Cells from Term Human Pregnancies Show Distinctive Functional Properties Related to the Induction of Labor

Overview

Journal Am J Reprod Immunol

Specialties Allergy & Immunology
Reproductive Medicine

Date 2013 Nov 30

PMID 24286217

Citations 23

Authors

Marisol Castillo-Castrejon

Noemi Meraz-Cruz

Nardhy Gomez-Lopez

Arturo Flores-Pliego

Jorge Beltran-Montoya

Martin Viveros-Alcaraz

Felipe Vadillo-Ortega

Affiliations

Soon will be listed here.

Abstract

Problem: Human parturition is associated with an intrauterine pro-inflammatory environment in the choriodecidua. Evidence that some mediators of this signaling cascade also elicit responses leading to labor prompted us to characterize the cellular sources of these mediators in the human choriodecidua.

Method Of Study: Leukocyte-enriched preparations from human choriodecidua (ChL) and intervillous placental blood leukocytes (PL) were maintained in culture. Secretions of inflammatory cytokines, chemokines, and MMP-9 were documented. Leukocyte phenotype of ChL and PL was determined by flow cytometry using specific fluorochrome-conjugated antibodies.

Results And Conclusions: ChL showed a distinct pro-inflammatory secretion pattern of cytokines and chemokines when compared with PL, including higher amounts of TNF-α and IL-6, and decreased secretions of IL-4 and IL-1ra. ChL also secreted more MIP-1α and MCP-1 and MMP-9 than PL. No significant differences were found in leukocytes subsets between compartments. Based on our findings, we propose that ChL isolated from fetal membranes at term are functionally different from PL and may collaborate to modulate the microenvironment linked to induction and progression of human labor.

Citing Articles

Clinical chorioamnionitis at term is characterized by changes in the plasma concentration of CHCHD2/MNRR1, a mitochondrial protein.

Bosco M, Romero R, Gallo D, Suksai M, Gotsch F, Jung E J Matern Fetal Neonatal Med. 2023; 36(2):2222333.

PMID: 37349086 PMC: 10445405. DOI: 10.1080/14767058.2023.2222333.

The amniotic fluid proteome changes with term labor and informs biomarker discovery in maternal plasma.

Bhatti G, Romero R, Gomez-Lopez N, Chaiworapongsa T, Than N, Theis K Sci Rep. 2023; 13(1):3136.

PMID: 36823217 PMC: 9950459. DOI: 10.1038/s41598-023-28157-3.

Epithelial to mesenchymal transition (EMT) of feto-maternal reproductive tissues generates inflammation: a detrimental factor for preterm birth.

Menon R BMB Rep. 2022; 55(8):370-379.

PMID: 35880430 PMC: 9442346.

Clarithromycin prevents preterm birth and neonatal mortality by dampening alarmin-induced maternal-fetal inflammation in mice.

Galaz J, Romero R, Arenas-Hernandez M, Farias-Jofre M, Motomura K, Liu Z BMC Pregnancy Childbirth. 2022; 22(1):503.

PMID: 35725425 PMC: 9210693. DOI: 10.1186/s12884-022-04764-2.

Transcriptome changes in maternal peripheral blood during term parturition mimic perturbations preceding spontaneous preterm birth†.

Gomez-Lopez N, Romero R, Galaz J, Bhatti G, Done B, Miller D Biol Reprod. 2021; 106(1):185-199.

PMID: 34686873 PMC: 8897989. DOI: 10.1093/biolre/ioab197.

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