The Effect of Relaxin on the Musculoskeletal System

Overview

Journal Scand J Med Sci Sports

Specialty Orthopedics

Date 2013 Nov 29

PMID 24283470

Citations 49

Authors

F Dehghan

B S Haerian

S Muniandy

A Yusof

J L Dragoo

N Salleh

Affiliations

Soon will be listed here.

Abstract

Relaxin is a hormone structurally related to insulin and insulin-like growth factor, which exerts its regulatory effect on the musculoskeletal and other systems through binding to its receptor in various tissues, mediated by different signaling pathways. Relaxin alters the properties of cartilage and tendon by activating collagenase. This hormone is also involved in bone remodeling and healing of injured ligaments and skeletal muscle. In this review, we have summarized the literature on the effect of relaxin in musculoskeletal system to provide a broad perspective for future studies in this field.

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References

Wojtys E, Huston L, Boynton M, Spindler K, Lindenfeld T . The effect of the menstrual cycle on anterior cruciate ligament injuries in women as determined by hormone levels. Am J Sports Med. 2002; 30(2):182-8. DOI: 10.1177/03635465020300020601. View

Ferlin A, Pepe A, Facciolli A, Gianesello L, Foresta C . Relaxin stimulates osteoclast differentiation and activation. Bone. 2009; 46(2):504-13. DOI: 10.1016/j.bone.2009.10.007. View

Dragoo J, Lee R, Benhaim P, Finerman G, Hame S . Relaxin receptors in the human female anterior cruciate ligament. Am J Sports Med. 2003; 31(4):577-84. DOI: 10.1177/03635465030310041701. View

Sato K, Li Y, Foster W, Fukushima K, Badlani N, Adachi N . Improvement of muscle healing through enhancement of muscle regeneration and prevention of fibrosis. Muscle Nerve. 2003; 28(3):365-72. DOI: 10.1002/mus.10436. View

Dragoo J, Castillo T, Braun H, Ridley B, Kennedy A, Golish S . Prospective correlation between serum relaxin concentration and anterior cruciate ligament tears among elite collegiate female athletes. Am J Sports Med. 2011; 39(10):2175-80. DOI: 10.1177/0363546511413378. View

Garibay-Tupas J, Okazaki K, Tashima L, Yamamoto S, Bryant-Greenwood G . Regulation of the human relaxin genes H1 and H2 by steroid hormones. Mol Cell Endocrinol. 2004; 219(1-2):115-25. DOI: 10.1016/j.mce.2004.01.004. View

Formigli L, Francini F, Chiappini L, Zecchi-Orlandini S, Bani D . Relaxin favors the morphofunctional integration between skeletal myoblasts and adult cardiomyocytes in coculture. Ann N Y Acad Sci. 2005; 1041:444-5. DOI: 10.1196/annals.1282.067. View

Faryniarz D, Bhargava M, Lajam C, Attia E, Hannafin J . Quantitation of estrogen receptors and relaxin binding in human anterior cruciate ligament fibroblasts. In Vitro Cell Dev Biol Anim. 2006; 42(7):176-81. DOI: 10.1290/0512089.1. View

Masini E, Nistri S, Vannacci A, Bani Sacchi T, Novelli A, Bani D . Relaxin inhibits the activation of human neutrophils: involvement of the nitric oxide pathway. Endocrinology. 2003; 145(3):1106-12. DOI: 10.1210/en.2003-0833. View

10.

Mendias C, Tatsumi R, Allen R . Role of cyclooxygenase-1 and -2 in satellite cell proliferation, differentiation, and fusion. Muscle Nerve. 2004; 30(4):497-500. DOI: 10.1002/mus.20102. View

11.

Santora K, Rasa C, Visco D, Steinetz B, Bagnell C . Effects of relaxin in a model of rat adjuvant-induced arthritis. Ann N Y Acad Sci. 2005; 1041:481-5. DOI: 10.1196/annals.1282.072. View

12.

Chistyakova O, Kuznetsova L . Effect of peptides of the insulin superfamily on glucose-6-phosphate dehydrogenase activity in skeletal muscles of river lamprey (Lampetra fluviatilis) during prespawning starvation. Bull Exp Biol Med. 2009; 148(1):29-32. DOI: 10.1007/s10517-009-0632-x. View

13.

Wood M, Luthin W, Lester G, Dahners L . Tendon creep is potentiated by NKISK and relaxin which produce collagen fiber sliding. Iowa Orthop J. 2003; 23:75-9. PMC: 1888401. View

14.

Schauberger C, Rooney B, Goldsmith L, Shenton D, Silva P, Schaper A . Peripheral joint laxity increases in pregnancy but does not correlate with serum relaxin levels. Am J Obstet Gynecol. 1996; 174(2):667-71. DOI: 10.1016/s0002-9378(96)70447-7. View

15.

Qin X, Chua P, Cachola L, Bryant-Greenwood G . An autocrine/paracrine role of human decidual relaxin. I. Interstitial collagenase (matrix metalloproteinase-1) and tissue plasminogen activator. Biol Reprod. 1997; 56(4):800-11. DOI: 10.1095/biolreprod56.4.800. View

16.

Hashem G, Zhang Q, Hayami T, Chen J, Wang W, Kapila S . Relaxin and beta-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss. Arthritis Res Ther. 2006; 8(4):R98. PMC: 1779373. DOI: 10.1186/ar1978. View

17.

Slauterbeck J, Fuzie S, Smith M, Clark R, Xu K, Starch D . The Menstrual Cycle, Sex Hormones, and Anterior Cruciate Ligament Injury. J Athl Train. 2003; 37(3):275-278. PMC: 164356. View

18.

Koay E, Too C, GREENWOOD F, Bryant-Greenwood G . Relaxin stimulates collagenase and plasminogen activator secretion by dispersed human amnion and chorion cells in vitro. J Clin Endocrinol Metab. 1983; 56(6):1332-4. DOI: 10.1210/jcem-56-6-1332. View

19.

Facciolli A, Ferlin A, Gianesello L, Pepe A, Foresta C . Role of relaxin in human osteoclastogenesis. Ann N Y Acad Sci. 2009; 1160:221-5. DOI: 10.1111/j.1749-6632.2008.03788.x. View

20.

Toth A, Cordasco F . Anterior cruciate ligament injuries in the female athlete. J Gend Specif Med. 2001; 4(4):25-34. View