Antioxidant Therapies for the Management of Atrial Fibrillation

Overview

Journal Cardiovasc Diagn Ther

Publisher AME Publishing Company

Specialty Cardiology & Vascular Diseases

Date 2013 Nov 28

PMID 24282730

Citations 9

Authors

Tong Liu

Panagiotis Korantzopoulos

Guangping Li

Affiliations

Soon will be listed here.

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice, representing a major public health problem. Recent evidence suggests oxidative stress may play an important role in the pathogenesis and perpetuation of AF. In the past few years, experimental data and clinical evidence have tested the concept of antioxidant therapies to prevent AF. Besides statins, ACE-inhibitors (ACEIs) and/or angiotensin-receptor blockers (ARBs), and omega-3 polyunsaturated fatty acids, several other interventions with antioxidant properties, such as Vitamin C and E, thiazolidinediones, N-acetylcysteine, probucol, nitric oxide donors or precursors, NADPH oxidase inhibitors, Xanthine oxidase inhibitors have emerged as novel strategies for the management of AF. We aim to review recent evidence regarding antioxidant therapies in the prevention and treatment of atrial fibrillation.

Citing Articles

Efficacy of N-acetylcysteine for Prevention of Postoperative Atrial Fibrillation Following Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Hanafy D, Willim H, Trianita Suwatri W, Sani A, Khouw H, Susanti E Rev Cardiovasc Med. 2024; 25(7):243.

PMID: 39139444 PMC: 11317354. DOI: 10.31083/j.rcm2507243.

Antioxidants in Arrhythmia Treatment-Still a Controversy? A Review of Selected Clinical and Laboratory Research.

Szyller J, Jagielski D, Bil-Lula I Antioxidants (Basel). 2022; 11(6).

PMID: 35740006 PMC: 9220256. DOI: 10.3390/antiox11061109.

Mechanisms Underlying Antiarrhythmic Properties of Cardioprotective Agents Impacting Inflammation and Oxidative Stress.

Andelova K, Szeiffova Bacova B, Sykora M, Hlivak P, Barancik M, Tribulova N Int J Mol Sci. 2022; 23(3).

PMID: 35163340 PMC: 8835881. DOI: 10.3390/ijms23031416.

Antioxidant defence and oxidative stress markers in cats with asymptomatic and symptomatic hypertrophic cardiomyopathy: a pilot study.

Michalek M, Tabis A, Paslawska U, Noszczyk-Nowak A BMC Vet Res. 2020; 16(1):26.

PMID: 32000761 PMC: 6990494. DOI: 10.1186/s12917-020-2256-3.

A retrospective study on atrial fibrillation after coronary artery bypass grafting surgery at The National Heart Institute, Kuala Lumpur.

Musa A, Quan C, Xin L, Soni T, Dillon J, Kah Hay Y F1000Res. 2018; 7:164.

PMID: 30254739 PMC: 6127737. DOI: 10.12688/f1000research.13244.2.

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