Comparison of Locoregional Recurrence with Mastectomy Vs. Breast Conserving Surgery in Pregnancy Associated Breast Cancer (PABC)

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2013 Nov 28

PMID 24280969

Citations 2

Authors

Sushil Beriwal

Bunja Rungruang

Atilla Soran

Darcy Thull

Joseph L Kelley

Rohit Bhargava

Chyongchiou J Lin

Paniti Sukumvanich

Affiliations

Soon will be listed here.

Abstract

We have compared outcomes, including the locoregional recurrence, between mastectomy and breast conserving therapy in PABC. Patients were divided into those who were treated with mastectomies (group 1) and those with breast conserving surgery (group 2). The groups were comparable except for lower mean age in group 2 and more patients with stage III disease and higher number of nodes positive in the group 1. Five-year actuarial LRR, distant metastases free survival and overall survival in group 1 vs. 2 were 10% vs. 37%, 73% vs. 81% and 57% vs. 59% respectively. The patients with PABC treated with breast conserving therapy, despite having lower stage disease, have a higher risk of local regional recurrence in comparison with those treated with mastectomy.

Citing Articles

Clinicopathologic features, treatment, and prognosis of pregnancy-associated breast cancer.

Li Y, Wang Y, Sun Q, Shen S Front Oncol. 2023; 12:978671.

PMID: 36591448 PMC: 9795172. DOI: 10.3389/fonc.2022.978671.

Surgery on breast cancer in pregnancy.

Liberale V, Tripodi E, Ottino L, Biglia N Transl Cancer Res. 2022; 8(Suppl 5):S493-S502.

PMID: 35117127 PMC: 8797300. DOI: 10.21037/tcr.2019.07.16.

References

Recht A, Connolly J, Schnitt S, Silver B, Rose M, Love S . The effect of young age on tumor recurrence in the treated breast after conservative surgery and radiotherapy. Int J Radiat Oncol Biol Phys. 1988; 14(1):3-10. DOI: 10.1016/0360-3016(88)90043-0. View

Kuerer H, Gwyn K, Ames F, Theriault R . Conservative surgery and chemotherapy for breast carcinoma during pregnancy. Surgery. 2002; 131(1):108-10. DOI: 10.1067/msy.2002.115357. View

PARENTE J, Amsel M, Lerner R, Chinea F . Breast cancer associated with pregnancy. Obstet Gynecol. 1988; 71(6 Pt 1):861-4. View

Kurtz J, Spitalier J, Amalric R, BRANDONE H, AYME Y, Bressac C . Mammary recurrences in women younger than forty. Int J Radiat Oncol Biol Phys. 1988; 15(2):271-6. DOI: 10.1016/s0360-3016(98)90004-9. View

Middleton L, Amin M, Gwyn K, Theriault R, Sahin A . Breast carcinoma in pregnant women: assessment of clinicopathologic and immunohistochemical features. Cancer. 2003; 98(5):1055-60. DOI: 10.1002/cncr.11614. View

Beadle B, Woodward W, Tucker S, Outlaw E, Allen P, Oh J . Ten-year recurrence rates in young women with breast cancer by locoregional treatment approach. Int J Radiat Oncol Biol Phys. 2008; 73(3):734-44. PMC: 3041273. DOI: 10.1016/j.ijrobp.2008.04.078. View

Elkhuizen P, van de Vijver M, Hermans J, Zonderland H, van de Velde C, Leer J . Local recurrence after breast-conserving therapy for invasive breast cancer: high incidence in young patients and association with poor survival. Int J Radiat Oncol Biol Phys. 1998; 40(4):859-67. DOI: 10.1016/s0360-3016(97)00917-6. View

Bernik S, Bernik T, Whooley B, Wallack M . Carcinoma of the breast during pregnancy: a review and update on treatment options. Surg Oncol. 1999; 7(1-2):45-9. DOI: 10.1016/s0960-7404(98)00022-x. View

Kim S, Tran K, MacLean B, Borgen P . Women 35 years of age or younger have higher locoregional relapse rates after undergoing breast conservation therapy. J Am Coll Surg. 1998; 187(1):1-8. DOI: 10.1016/s1072-7515(98)00114-8. View

10.

Nixon A, Neuberg D, Hayes D, Gelman R, Connolly J, Schnitt S . Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer. J Clin Oncol. 1994; 12(5):888-94. DOI: 10.1200/JCO.1994.12.5.888. View

11.

De La Rochefordiere A, Asselain B, Campana F, Scholl S, Fenton J, Vilcoq J . Age as prognostic factor in premenopausal breast carcinoma. Lancet. 1993; 341(8852):1039-43. DOI: 10.1016/0140-6736(93)92407-k. View

12.

Zemlickis D, Lishner M, Degendorfer P, Panzarella T, Burke B, Sutcliffe S . Maternal and fetal outcome after breast cancer in pregnancy. Am J Obstet Gynecol. 1992; 166(3):781-7. DOI: 10.1016/0002-9378(92)91334-7. View

13.

HAAGENSEN C, STOUT A . CARCINOMA OF THE BREAST: II. CRITERIA OF OPERABILITY. Ann Surg. 1943; 118(5):859-70. PMC: 1617728. DOI: 10.1097/00000658-194311850-00008. View

14.

de Bock G, van der Hage J, Putter H, Bonnema J, Bartelink H, van de Velde C . Isolated loco-regional recurrence of breast cancer is more common in young patients and following breast conserving therapy: long-term results of European Organisation for Research and Treatment of Cancer studies. Eur J Cancer. 2005; 42(3):351-6. DOI: 10.1016/j.ejca.2005.10.006. View

15.

Ezzat A, Raja M, Berry J, Zwaan F, Jamshed A, Rhydderch D . Impact of pregnancy on non-metastatic breast cancer: a case control study. Clin Oncol (R Coll Radiol). 1996; 8(6):367-70. DOI: 10.1016/s0936-6555(96)80081-1. View

16.

Ives A, Saunders C, Semmens J . The Western Australian gestational breast cancer project: a population-based study of the incidence, management and outcomes. Breast. 2005; 14(4):276-82. DOI: 10.1016/j.breast.2005.02.008. View

17.

Beadle B, Woodward W, Middleton L, Tereffe W, Strom E, Litton J . The impact of pregnancy on breast cancer outcomes in women<or=35 years. Cancer. 2009; 115(6):1174-84. PMC: 3063387. DOI: 10.1002/cncr.24165. View

18.

Carey L, Dees E, Sawyer L, Gatti L, Moore D, Collichio F . The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res. 2007; 13(8):2329-34. DOI: 10.1158/1078-0432.CCR-06-1109. View

19.

Albain K, Allred D, Clark G . Breast cancer outcome and predictors of outcome: are there age differentials?. J Natl Cancer Inst Monogr. 1994; (16):35-42. View

20.

Kurtz J, Jacquemier J, Amalric R, BRANDONE H, AYME Y, Hans D . Why are local recurrences after breast-conserving therapy more frequent in younger patients?. J Clin Oncol. 1990; 8(4):591-8. DOI: 10.1200/JCO.1990.8.4.591. View