Clinical Pharmacology in Old Persons

Overview

Journal Scientifica (Cairo)

Publisher Wiley

Specialty Biology

Date 2013 Nov 27

PMID 24278735

Citations 19

Authors

Paul A F Jansen

Jacobus R B J Brouwers

Affiliations

Soon will be listed here.

Abstract

The epidemiological transition, with a rapid increase in the proportion in the global population aged over 65 years from 11% in 2010 to 22% in 2050 and 32% in 2100, represents a challenge for public health. More and more old persons have multimorbidities and are treated with a large number of medicines. In advanced age, the pharmacokinetics and pharmacodynamics of many drugs are altered. In addition, pharmacotherapy may be complicated by difficulties with obtaining drugs or adherence and persistence with drug regimens. Safe and effective pharmacotherapy remains one of the greatest challenges in geriatric medicine. In this paper, the main principles of geriatric pharmacology are presented.

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