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A Transfer of Silver Nanoparticles from Pregnant Rat to Offspring

Overview
Journal Toxicol Res
Specialty Toxicology
Date 2013 Nov 27
PMID 24278602
Citations 17
Authors
Yeonjin Lee
Jonghye Choi
Pilje Kim
Kyunghee Choi
Suhyon Kim
Woochan Shon
Kwangsik Park
Affiliations
Soon will be listed here.
Abstract

7.9 ± 0.95 nm, dosage: 250 mg/kg) were orally administered to pregnant rats. At 4 days after parturition, four pups were randomly selected (one pup from one dam) and silver level in liver, kidney, lung and brain was determined by ICP-MS and electron microscope. As results, silver nanoparticles highly accumulated in the tissues of the pups. Silver level in the treated group was 132.4 ± 43.9 ng/g in the kidney (12.3 fold compared to control group), 37.3 ± 11.3 ng/g in the liver (7.9 fold), 42.0 ± 8.6 ng/g in the lung (5.9 fold), and 31.1 ± 4.3 ng/g in the brain (5.4 fold). This result suggested that the possible transfer of silver nanoparticles from pregnant dams to the fetus through mainly placenta.

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