Centella Asiatica in Cosmetology

Overview

Journal Postepy Dermatol Alergol

Publisher Termedia

Specialty Allergy & Immunology

Date 2013 Nov 27

PMID 24278045

Citations 48

Authors

Wieslawa Bylka

Paulina Znajdek-Awizen

Elzbieta Studzinska-Sroka

Malgorzata Brzezinska

Affiliations

Soon will be listed here.

Abstract

Centella asiatica known as Gotu Kola is a medicinal plant that has been used in folk medicine for hundreds of years as well as in scientifically oriented medicine. The active compounds include pentacyclic triterpenes, mainly asiaticoside, madecassoside, asiatic and madecassic acids. Centella asiatica is effective in improving treatment of small wounds, hypertrophic wounds as well as burns, psoriasis and scleroderma. The mechanism of action involves promoting fibroblast proliferation and increasing the synthesis of collagen and intracellular fibronectin content and also improvement of the tensile strength of newly formed skin as well as inhibiting the inflammatory phase of hypertrophic scars and keloids. Research results indicate that it can be used in the treatment of photoaging skin, cellulite and striae.

Citing Articles

Eating "rubbish"? Exploring the herbal secrets of "Laji-He," a traditional herbal rice snack from southern China.

Hu R, Wang Q, Duan Z, Hu Y, Lai K, Cai X J Ethnobiol Ethnomed. 2025; 21(1):4.

PMID: 39825446 PMC: 11740551. DOI: 10.1186/s13002-025-00754-8.

Controlled Release of Madecassoside and Asiaticoside of L. Origin from Sustainable Cold-Processed Topical Formulations.

Krzyzostan M, Wawrzynczak A, Nowak I Molecules. 2024; 29(23).

PMID: 39683743 PMC: 11643272. DOI: 10.3390/molecules29235583.

Research Progress on Chitosan Microneedle Arrays in Transdermal Drug Delivery.

Li H, Cui J, Zhang T, Lin F, Zhang G, Feng Z Int J Nanomedicine. 2024; 19():12957-12973.

PMID: 39651356 PMC: 11624690. DOI: 10.2147/IJN.S487313.

Giant , a novel cultivar rich in madecassoside and asiaticoside, suppresses α‑melanocyte‑stimulating hormone‑induced melanogenesis through MC1R binding.

Seo J, Jeong C, Oh S, Lee S, Park H, Seo D Int J Mol Med. 2024; 55(1).

PMID: 39513603 PMC: 11573313. DOI: 10.3892/ijmm.2024.5454.

Effects of Plant Meristem-Cell-Based Cosmetics on Menopausal Skin: Clinical Data and Mechanisms.

Korkina L, Kharaeva Z, Shokarova A, Barokova E, Mayer W, Trakhtman I Biomolecules. 2024; 14(9).

PMID: 39334942 PMC: 11429794. DOI: 10.3390/biom14091176.

References

Shetty B, Udupa S, Udupa A, Somayaji S . Effect of Centella asiatica L (Umbelliferae) on normal and dexamethasone-suppressed wound healing in Wistar Albino rats. Int J Low Extrem Wounds. 2006; 5(3):137-43. DOI: 10.1177/1534734606291313. View

Guseva N, Starovoitova M, Mach E . [Madecassol treatment of systemic and localized scleroderma]. Ter Arkh. 1998; 70(5):58-61. View

Shukla A, Rasik A, Dhawan B . Asiaticoside-induced elevation of antioxidant levels in healing wounds. Phytother Res. 1999; 13(1):50-4. DOI: 10.1002/(SICI)1099-1573(199902)13:1<50::AID-PTR368>3.0.CO;2-V. View

Lee J, Jung E, Kim Y, Park J, Park J, Hong S . Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling. Planta Med. 2006; 72(4):324-8. DOI: 10.1055/s-2005-916227. View

Rossi A, Vergnanini A . Cellulite: a review. J Eur Acad Dermatol Venereol. 2001; 14(4):251-62. DOI: 10.1046/j.1468-3083.2000.00016.x. View

Lu L, Ying K, Wei S, Liu Y, Lin H, Mao Y . Dermal fibroblast-associated gene induction by asiaticoside shown in vitro by DNA microarray analysis. Br J Dermatol. 2004; 151(3):571-8. DOI: 10.1111/j.1365-2133.2004.06146.x. View

Haftek M, Mac-Mary S, Le Bitoux M, Creidi P, Seite S, Rougier A . Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin. Exp Dermatol. 2008; 17(11):946-52. DOI: 10.1111/j.1600-0625.2008.00732.x. View

Hashim P, Sidek H, Helan M, Sabery A, Palanisamy U, Ilham M . Triterpene composition and bioactivities of Centella asiatica. Molecules. 2011; 16(2):1310-22. PMC: 6259745. DOI: 10.3390/molecules16021310. View

Antognoni F, Perellino N, Crippa S, Dal Toso R, Danieli B, Minghetti A . Irbic acid, a dicaffeoylquinic acid derivative from Centella asiatica cell cultures. Fitoterapia. 2011; 82(7):950-4. DOI: 10.1016/j.fitote.2011.05.008. View

10.

Maquart F, Chastang F, Simeon A, Birembaut P, Gillery P, Wegrowski Y . Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. Eur J Dermatol. 1999; 9(4):289-96. View

11.

. Centella asiatica. Altern Med Rev. 2007; 12(1):69-72. View

12.

Bosse J, Papillon J, Frenette G, Dansereau J, Cadotte M, Le Lorier J . Clinical study of a new antikeloid agent. Ann Plast Surg. 1979; 3(1):13-21. View

13.

Shukla A, Rasik A, Jain G, Shankar R, Kulshrestha D, Dhawan B . In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacol. 1999; 65(1):1-11. DOI: 10.1016/s0378-8741(98)00141-x. View

14.

Liu M, Dai Y, Li Y, Luo Y, Huang F, Gong Z . Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice. Planta Med. 2008; 74(8):809-15. DOI: 10.1055/s-2008-1074533. View

15.

Gohil K, Patel J, Gajjar A . Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all. Indian J Pharm Sci. 2011; 72(5):546-56. PMC: 3116297. DOI: 10.4103/0250-474X.78519. View

16.

Mallol J, Belda M, Costa D, Noval A, Sola M . Prophylaxis of Striae gravidarum with a topical formulation. A double blind trial. Int J Cosmet Sci. 2009; 13(1):51-7. DOI: 10.1111/j.1467-2494.1991.tb00547.x. View

17.

Sampson J, Raman A, Karlsen G, Navsaria H, Leigh I . In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins. Phytomedicine. 2001; 8(3):230-5. DOI: 10.1078/0944-7113-00032. View

18.

Widgerow A, Chait L, Stals R, Stals P . New innovations in scar management. Aesthetic Plast Surg. 2000; 24(3):227-34. DOI: 10.1007/s002660010038. View

19.

Kimura Y, Sumiyoshi M, Samukawa K, Satake N, Sakanaka M . Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism. Eur J Pharmacol. 2008; 584(2-3):415-23. DOI: 10.1016/j.ejphar.2008.02.036. View

20.

Brinkhaus B, Lindner M, Schuppan D, Hahn E . Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica. Phytomedicine. 2000; 7(5):427-48. DOI: 10.1016/s0944-7113(00)80065-3. View