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Importance of Structural Free Space to the Solvent Power of Water

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Journal Pharm Res
Specialties Pharmacology
Pharmacy
Date 2013 Nov 27
PMID 24277252
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Abstract

The contribution of structural free space to the solvent power of water was examined by a systematic modification of the geometric factor. Gaps and holes, available to foreign molecule occupation, are thought to be filled at low concentrations (max. 1 %) of aliphatic alcohols. The effect upon solvency reached approximately 10%, which suggests that spatial parameters affect solvent power. The results demonstrate the importance of solvent purity in the dissolution process.

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