Severe Vitamin D Deficiency in a Patient with Sickle Cell Disease: a Case Study with Literature Review

Purpose: Vitamin D is essential for the normal absorption of calcium and to maintain calcium homeostasis. Vitamin D deficiency results in rickets, osteomalacia, and bony changes in the spine. Sickle cell disease patients are at an increased risk of vitamin D deficiency.

Case Presentation: We describe a case of severe vitamin D deficiency and response to vitamin D supplementation in a patient with sickle cell disease.

Conclusions: Currently, there are no recommendations for calcium and vitamin D supplementation in sickle cell patients. Vitamin D deficiency in these patients may be due to poor absorption.