Epidemiology and Differential Diagnosis of Nasal Polyps

Overview

Journal Am J Rhinol Allergy

Publisher Sage Publications

Specialties Allergy & Immunology
Otorhinolaryngology

Date 2013 Nov 27

PMID 24274222

Citations 54

Authors

Mohamad R Chaaban

Erika M Walsh

Bradford A Woodworth

Affiliations

Soon will be listed here.

Abstract

Background: Chronic rhinosinusitis (CRS) is one of the most common chronic medical conditions, with a significant impact on patient quality of life. CRS is broadly classified into two groups: CRS with nasal polyposis (CRSwNP) and CRS without NP (CRSsNP). Clinically, the major subtypes of CRSwNP may be divided into eosinophilic chronic rhinosinusitis (e.g., allergic fungal rhinosinusitis and aspirin-exacerbated respiratory disease [AERD]) and nasal polyps associated with neutrophilic inflammation (e.g., cystic fibrosis [CF]). CF is characterized by mutation of the gene encoding the CF transmembrane conductance regulator. Functional endoscopic sinus surgery is usually required for most NP patients with increased frequency in patients with AERD. This study provides a review of the epidemiology and major classification of CRSwNP.

Methods: A review was performed of the literature regarding different subtypes of CRSwNP.

Results: Many definitions of CRSwNP exist and estimates of prevalence vary.

Conclusion: CRSwNP is a clinical syndrome with a heterogeneous inflammatory profile. Of the subtypes associated with eosinophilic inflammation, AERD remains the most recalcitrant to medical and surgical therapeutic interventions.

Citing Articles

Clinical effectiveness of dupilumab in CRSwNP: unaffected by baseline nasal polyp size in real-world settings.

Habenbacher M, Moser U, Abaira A, Kiss P, Holzmeister C, Pock J Eur Arch Otorhinolaryngol. 2025; .

PMID: 39979624 DOI: 10.1007/s00405-025-09275-2.

Effect of Dupilumab in CRSwNP Sinonasal Outcomes from Real Life Studies: A Systematic Review with Meta-analysis.

Rodriguez-Iglesias M, Calvo-Henriquez C, Martin-Jimenez D, Garcia-LLiberos A, Maza-Solano J, Moreno-Luna R Curr Allergy Asthma Rep. 2025; 25(1):13.

PMID: 39907855 PMC: 11799128. DOI: 10.1007/s11882-025-01192-y.

Impact of FESS on symptomatology and quality of life of patients with CRSsNP.

Romano A, Barone S, Borriello G, De Fazio G, Paesano S, Grassia G Eur Arch Otorhinolaryngol. 2024; .

PMID: 39702803 DOI: 10.1007/s00405-024-09139-1.

Investigation of Blood Count-Based Inflammatory Biomarkers as Predictors of Response to Dupilumab Treatment in Patients with Chronic Rhinosinusitis with Nasal Polyps.

Habenbacher M, Moser U, Abaira A, Kiss P, Holzmeister C, Pock J Pharmaceutics. 2024; 16(11).

PMID: 39598494 PMC: 11597114. DOI: 10.3390/pharmaceutics16111370.

Impact of Overweight on Response to Dupilumab Treatment in Chronic Rhinosinusitis with Nasal Polyps.

Habenbacher M, Moser U, Abaira A, Tomazic P, Kiss P, Holzmeister C Nutrients. 2024; 16(17).

PMID: 39275297 PMC: 11397523. DOI: 10.3390/nu16172982.

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