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The Effect of Juglone on Cholinergic Mechanisms in Rat Brain Synaptosomes

Overview
Journal Neurochem Res
Specialties Chemistry
Neurology
Date 2013 Nov 26
PMID 24272053
Authors
J R Cooper
K Piros
Affiliations
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Abstract

Juglone 5-hydroxy-1,4-napthoquinone exerts three activities on cortical synaptosomal preparations. It inhibits the release of acetylcholine and is an even more potent inhibitor of high-affinity choline transport into synaptosomes. In addition, as has already been shown by others using brain homogenates, juglone inhibits choline acetyltransferase.

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