Metabolism of Plasma Cholesterol and Lipoprotein Parameters Are Related to a Higher Degree of Insulin Sensitivity in High HDL-C Healthy Normal Weight Subjects

Overview

Journal Cardiovasc Diabetol

Publisher Biomed Central

Specialties Cardiology & Vascular Diseases
Endocrinology

Date 2013 Nov 26

PMID 24267726

Citations 11

Authors

Camila C Leanca

Valeria S Nunes

Natalia B Panzoldo

Vanessa S Zago

Eliane S Parra

Patricia M Cazita

Matti Jauhiainen

Marisa Passarelli

Edna R Nakandakare

Eliana C de Faria

Eder C R Quintao

Affiliations

Soon will be listed here.

Abstract

Background: We have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects.

Methods: We have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-₁HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption.

Results: In the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-₁HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities.

Conclusions: These findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity.

Citing Articles

The Plasma Distribution of Non-cholesterol Sterol Precursors and Products of Cholesterol Synthesis and Phytosterols Depend on HDL Concentration.

Nunes V, da Silva E, Ferreira G, Assis S, Cazita P, Nakandakare E Front Nutr. 2022; 9:723555.

PMID: 35299760 PMC: 8921769. DOI: 10.3389/fnut.2022.723555.

Endothelin-1 in the pathophysiology of obesity and insulin resistance.

Jenkins H, Rivera-Gonzalez O, Gibert Y, Speed J Obes Rev. 2020; 21(12):e13086.

PMID: 32627269 PMC: 7669671. DOI: 10.1111/obr.13086.

The coronary artery calcium score is linked to plasma cholesterol synthesis and absorption markers: Brazilian Longitudinal Study of Adult Health.

Nunes V, Bensenor I, Lotufo P, Passarelli M, Nakandakare E, Quintao E Biosci Rep. 2020; 40(7).

PMID: 32579186 PMC: 7332684. DOI: 10.1042/BSR20201094.

Type V hypertriglyceridemia in children, a therapeutic challenge in pediatrics: A case report and a review of the literature.

Marginean C, Melit L, Dobreanu M, Marginean M Medicine (Baltimore). 2018; 96(51):e8864.

PMID: 29390422 PMC: 5758124. DOI: 10.1097/MD.0000000000008864.

Reference values assessment in a Mediterranean population for small dense low-density lipoprotein concentration isolated by an optimized precipitation method.

Fernandez-Cidon B, Padro-Miquel A, Alia-Ramos P, Castro-Castro M, Fanlo-Maresma M, Dot-Bach D Vasc Health Risk Manag. 2017; 13:201-207.

PMID: 28652759 PMC: 5472427. DOI: 10.2147/VHRM.S132475.

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