Advances in Immunopathogenesis of Adult Immune Thrombocytopenia

Overview

Journal Front Med

Specialty General Medicine

Date 2013 Nov 23

PMID 24264165

Citations 10

Authors

Xinguang Liu

Yu Hou

Jun Peng

Affiliations

Soon will be listed here.

Abstract

Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated accelerated platelet destruction and/or suppressed platelet production. Although the development of autoantibodies against platelet glycoproteins remains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immune modulation have been identified, and the pathways behind the immune-mediated destruction of platelets have opened new avenues for the design of specific immunotherapies in an attempt to reduce the platelet destruction. This review is primarily focused on the recent literature with respect to immunopathological mechanisms in patients with ITP.

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Deciphering the genetic basis of immune thrombocytopenia: current evidence for genetic predisposition in adult ITP.

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A Retrospective Analysis of the Treatment Approach to Immune Thrombocytopenia in the Real World.

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