Hydration of AMP and ATP Molecules in Aqueous Solution and Solid Films

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2013 Nov 23

PMID 24264037

Authors

Dzhigangir Faizullin

Nataliya Zakharchenko

Yuriy Zuev

Alexander Puzenko

Evgeniya Levy

Yuri Feldman

Affiliations

Soon will be listed here.

Abstract

Water enables life and plays a critical role in biology. Considered as a versatile and adaptive component of the cell, water engages a wide range of biomolecular interactions. An organism can exist and function only if its self-assembled molecular structures are hydrated. It was shown recently that switching of AMP/ATP binding to the insulin-independent glucose transporter Human Erythrocyte Glucose Transport Protein (GLUT1) may greatly influence the ratio of bulk and bound water during regulation of glucose uptake by red blood cells. In this paper, we present the results on the hydration properties of AMP/ATP obtained by means of dielectric spectroscopy in aqueous solution and for fully ionized forms in solid amorphous films with the help of gravimetric studies.

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