Acute Leukemia in a Patient Cured of Diffuse Histiocytic Lymphoma

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 1986 Jan 1

PMID 2426276

Authors

J P Dutcher

P H Wiernik

Affiliations

Soon will be listed here.

Abstract

A patient is described who, after completing treatment for diffuse histiocytic lymphoma, remained disease-free for 7 years (presumably cured), then developed acute nonlymphocytic leukemia (ANLL) after a brief preleukemic phase. Marrow cytogenetic analysis at the onset of frank leukemia revealed loss of chromosomes 5 and 7, which is consistent with secondary leukemia. She received only chemotherapy for her lymphoma, including high doses of an alkylating agent and a nitrosourea, which may have contributed to the development of the leukemia. This case report suggests that secondary ANLL may complicate the course of some long-term disease-free survivors of diffuse histiocytic lymphoma.

References

Schein P, Devita Jr V, Hubbard S, Chabner B, Canellos G, Berard C . Bleomycin, adriamycin, cyclophosphamide, vincristine, and prednisone (BACOP) combination chemotherapy in the treatment of advanced diffuse histiocytic lymphoma. Ann Intern Med. 1976; 85(4):417-22. DOI: 10.7326/0003-4819-85-4-417. View

Pedersen-Bjergaard J, Larsen S . Incidence of acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome up to 10 years after treatment of Hodgkin's disease. N Engl J Med. 1982; 307(16):965-71. DOI: 10.1056/NEJM198210143071601. View

Wilson B, VANSLYCK E . Coexistent lymphosarcoma and chronic granulocytic leukemia. Cancer. 1966; 19(6):809-16. DOI: 10.1002/1097-0142(196606)19:6<809::aid-cncr2820190610>3.0.co;2-v. View

Ezdinli E, Pocock S, BERARD C, AUNGST C, Silverstein M, Horton J . Comparison of intensive versus moderate chemotherapy of lymphocytic lymphomas: a progress report. Cancer. 1976; 38(3):1060-8. DOI: 10.1002/1097-0142(197609)38:3<1060::aid-cncr2820380304>3.0.co;2-v. View

Devita Jr V, Canellos G, Chabner B, Schein P, Hubbard S, Young R . Advanced diffuse histiocytic lymphoma, a potentially curable disease. Lancet. 1975; 1(7901):248-50. DOI: 10.1016/s0140-6736(75)91142-3. View

Cohen R, Wiernik P, Walker M . Acute nonlymphocytic leukemia associated with nitrosourea chemotherapy: report of two cases. Cancer Treat Rep. 1976; 60(9):1257-61. View

Fisher R, Devita Jr V, Johnson B, Simon R, Young R . Prognostic factors for advanced diffuse histiocytic lymphoma following treatment with combination chemotherapy. Am J Med. 1977; 63(2):177-82. DOI: 10.1016/0002-9343(77)90230-3. View

Lowenbraun S, SUTHERLAND J, Feldman M, SERPICK A . Transformation of reticulum cell sarcoma to acute leukemia. Cancer. 1971; 27(3):579-85. DOI: 10.1002/1097-0142(197103)27:3<579::aid-cncr2820270311>3.0.co;2-q. View

Gosselin G, Neemeh J, LONG L, Pretty H, Lefebvre R . [Appearance of acute myeloid leukemia during the development of lymphosarcoma]. Union Med Can. 1970; 99(5):866-70. View

10.

ZEFFREN J, Ultmann J . Recticulum cell sarcoma terminating in acute leukemia. Blood. 1960; 15:277-84. View

11.

Mosijczuk A, RUYMANN F . Second malignancy in acute lymphocytic leukemia. Review of 33 cases. Am J Dis Child. 1981; 135(4):313-6. DOI: 10.1001/archpedi.1981.02130280003002. View

12.

GUNZ F, LEVI J, Lind D, Vincent P . Development of acute leukaemia in a patient with lymphosarcoma. N Z Med J. 1973; 78(495):71-5. View

13.

Ellman L, Carey R . Morphological discordance in acute leukemia. Blood. 1976; 48(4):621-3. View

14.

Boice Jr J, Greene M, Killen Jr J, Ellenberg S, KEEHN R, McFadden E . Leukemia and preleukemia after adjuvant treatment of gastrointestinal cancer with semustine (methyl-CCNU). N Engl J Med. 1983; 309(18):1079-84. DOI: 10.1056/NEJM198311033091802. View

15.

Laszlo J, GRODE H . Granulocytic leukemia and reticulum cell sarcoma. Cancer. 1967; 20(4):545-51. DOI: 10.1002/1097-0142(1967)20:4<545::aid-cncr2820200412>3.0.co;2-0. View

16.

Greene M, Young R, Merrill J, DEVITA V . Evidence of a treatment dose response in acute nonlymphocytic leukemias which occur after therapy of non-Hodgkin's lymphoma. Cancer Res. 1983; 43(4):1891-8. View

17.

Jones S, Fuks Z, Bull M, Kadin M, DORFMAN R, Kaplan H . Non-Hodgkin's lymphomas. IV. Clinicopathologic correlation in 405 cases. Cancer. 1973; 31(4):806-23. DOI: 10.1002/1097-0142(197304)31:4<806::aid-cncr2820310408>3.0.co;2-1. View

18.

Youness E, Ahearn M, Drewinko B . Simultaneous occurrence of non-Hodgkin's lymphoma and spontaneous acute granulocytic leukemia. Am J Clin Pathol. 1978; 70(3):415-20. DOI: 10.1093/ajcp/70.3.415. View

19.

Kapadia S, Kaplan S . Simultaneous occurrence of non-Hodgkin's lymphoma and acute myelomonocytic leukemia. Cancer. 1976; 38(6):2557-60. DOI: 10.1002/1097-0142(197612)38:6<2557::aid-cncr2820380646>3.0.co;2-u. View

20.

ODonnell J, Brereton H, Greco F, Gralnick H, Johnson R . Acute nonlymphocytic leukemia and acute myeloproliferative syndrome following radiation therapy for non-Hodgkin's lymphoma and chronic lymphocytic leukemia: clinical studies. Cancer. 1979; 44(5):1930-8. DOI: 10.1002/1097-0142(197911)44:5<1930::aid-cncr2820440556>3.0.co;2-e. View