Cervical Ripening with Low-dose Prostaglandins in Planned Vaginal Birth After Cesarean

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Nov 22

PMID 24260505

Citations 4

Authors

Thomas Schmitz

Anne-Gaelle Pourcelot

Constance Moutafoff

Valerie Biran

Olivier Sibony

Jean-Francois Oury

Affiliations

Soon will be listed here.

Abstract

Objectives: To compare uterine rupture, maternal and perinatal morbidity rates in women with one single previous cesarean after spontaneous onset of labor or low-dose prostaglandin-induced cervical ripening for unfavourable cervix.

Study Design: This was a retrospective cohort study of 4,137 women with one single previous cesarean over a 22-year period. Inpatient prostaglandin administration consisted in single daily local applications.

Results: Vaginal delivery was planned for 3,544 (85.7%) patients, 2,704 (76.3%) of whom delivered vaginally (vaginal birth after Cesarean (VBAC) rate = 65.4%). Among women receiving prostaglandins (n=515), 323 (62.7%) delivered vaginally. Uterine rupture (0.7% compared with 0.8%, OR 1.1, 95% CI 0.4-3.4, p=0.88), maternal (0.9% compared with 1.2%, OR 1.3, 95% CI 0.5-3.2, p=0.63) and perinatal (0.3% compared with 0.8%, OR 2.4, 95% CI 0.7-8.5, p=0.18) morbidity rates did not differ significantly between patients with spontaneous onset of labor and those receiving prostaglandins, nor did these rates differ according to the planned mode of delivery.

Conclusion: In comparison with patients with spontaneous labor, inducing cervical ripening with low-dose prostaglandins in case of unfavourable cervix is not associated with appreciable increase in uterine rupture, maternal or perinatal morbidity.

Citing Articles

Planned mode of birth after previous cesarean section: A structured review of the evidence on the associated outcomes for women and their children in high-income setting.

Fitzpatrick K, Quigley M, Kurinczuk J Front Med (Lausanne). 2022; 9:920647.

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Maternal and neonatal outcomes associated with induction of labor after one previous cesarean delivery: A French retrospective study.

Vecchioli E, Cordier A, Chantry A, Benachi A, Monier I PLoS One. 2020; 15(8):e0237132.

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Obstetric outcome of induction of labor using prostaglandin gel in patients with previous one cesarean section.

Sangwan V, Siwach S, Lakra P, Sangwan M, Singh S, Mahendru R Obstet Gynecol Sci. 2019; 62(6):397-403.

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Misoprostol for Labour Induction after Previous Caesarean Section - Forever a "No Go"?.

Rath W, Tsikouras P Geburtshilfe Frauenheilkd. 2016; 75(11):1140-1147.

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