Animal Models of Pancreatitis: Can It Be Translated to Human Pain Study?

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2013 Nov 22

PMID 24259952

Citations 12

Authors

Jing-Bo Zhao

Dong-Hua Liao

Thomas Dahl Nissen

Affiliations

Soon will be listed here.

Abstract

Chronic pancreatitis affects many individuals around the world, and the study of the underlying mechanisms leading to better treatment possibilities are important tasks. Therefore, animal models are needed to illustrate the basic study of pancreatitis. Recently, animal models of acute and chronic pancreatitis have been thoroughly reviewed, but few reviews address the important aspect on the translation of animal studies to human studies. It is well known that pancreatitis is associated with epigastric pain, but the understanding regarding to mechanisms and appropriate treatment of this pain is still unclear. Using animal models to study pancreatitis associated visceral pain is difficult, however, these types of models are a unique way to reveal the mechanisms behind pancreatitis associated visceral pain. In this review, the animal models of acute, chronic and un-common pancreatitis are briefly outlined and animal models related to pancreatitis associated visceral pain are also addressed.

Citing Articles

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Wu J, Kuang W, Zhu Z, Dou J, Yao J, Cao J CNS Neurosci Ther. 2025; 31(3):e70313.

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Comparative Study of Non-invasive Mouse Models of Pancreatitis.

Swetha K, Indumathi M, Siddappa S, Chen C, Marathe G Dig Dis Sci. 2024; 70(1):233-244.

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Zhang J, Yang X, Xu X, Shen Q, Han F, Zhu Q J Clin Med. 2023; 12(7).

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Hemorheological and Microcirculatory Relations of Acute Pancreatitis.

Kotan R, Peto K, Deak A, Szentkereszty Z, Nemeth N Metabolites. 2023; 13(1).

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Vlavcheski F, ONeill E, Gagacev F, Tsiani E Molecules. 2022; 27(23).

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