Gene Polymorphisms and Chronic Obstructive Pulmonary Disease

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2013 Nov 22

PMID 24256364

Citations 13

Authors

Xiaodan Wu

Bowei Yuan

Elena Lopez

Chunxue Bai

Xiangdong Wang

Affiliations

Soon will be listed here.

Abstract

The genetic component was suggested to contribute to the development of chronic obstructive pulmonary disease (COPD), a major and growing public health burden. The present review aims to characterize the evidence that gene polymorphisms contribute to the aetiology of COPD and related traits, and explore the potential relationship between certain gene polymorphisms and COPD susceptibility, severity, lung function, phenotypes, or drug effects, even though limited results from related studies lacked consistency. Most of these studies were association studies, rather than confirmatory studies. More large-sized and strictly controlled studies are needed to prove the relationship between gene polymorphisms and the reviewed traits. More importantly, prospective confirmatory studies beyond initial association studies will be necessary to evaluate true relationships between gene polymorphisms and COPD and help individualized treatment for patients with COPD.

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