Efficacy of an Enuresis Alarm, Desmopressin, and Combination Therapy in the Treatment of Saudi Children with Primary Monosymptomatic Nocturnal Enuresis

Overview

Journal Korean J Urol

Specialty Urology

Date 2013 Nov 21

PMID 24255762

Citations 12

Authors

Abul-Fotouh Abdel-Maguid Ahmed

Moamen Mohammed Amin

Mahmoud Mohammed Ali

Essam Abdel-Moneim Shalaby

Affiliations

Soon will be listed here.

Abstract

Purpose: We evaluated and compared the effectiveness of an enuresis alarm, desmopressin medication, and their combination in the treatment of Saudi children with primary monosymptomatic nocturnal enuresis (PMNE).

Materials And Methods: A total of 136 children with PMNE were randomly assigned to receive an enuresis alarm alone (EA group, n=45), desmopressin alone (D group, n=46), or a combination of both (EA/D group, n=45). Patients were followed weekly during treatment and for 12 weeks after treatment withdrawal.

Results: During treatment, wetting frequencies were significantly reduced in all groups and remained significantly lower than pretreatment values until the end of follow-up. In the D and EA/D groups, an immediate reduction in wetting frequencies was observed, whereas a longer time was required to reach a significant reduction in the EA group. The full and partial response rates were 13.3% and 37.8% in the EA group, 26.1% and 43.5% in the D group, and 40.0% and 33.3% in the EA/D group. A significant difference was observed only between the EA and EA/D groups (p=0.025). Relapse rates were higher in the D group (66.6%) than in the EA (16.6%) and EA/D (33.3%) groups. A significant difference was observed between the D and EA groups only (p=0.019).

Conclusions: Desmopressin, an enuresis alarm, and combined therapy are effective in the treatment of Saudi children with PMNE. Desmopressin produced an immediate effect but relapses were common. The enuresis alarm provided gradual effects that persisted posttreatment. The combined therapy was superior to the alarm in achieving an immediate response; however, its effect was not better than that of the alarm long term.

Citing Articles

Monosymptomatic Nocturnal Enuresis Treatment Using Alarm-Therapy and Desmopressin: A Meta-analysis Approach.

Purnomo A, Daryanto B, Nurhadi P Med Arch. 2022; 75(6):431-435.

PMID: 35169370 PMC: 8810148. DOI: 10.5455/medarh.2021.75.431-435.

Alarm interventions for nocturnal enuresis in children.

Caldwell P, Codarini M, Stewart F, Hahn D, Sureshkumar P Cochrane Database Syst Rev. 2020; 5:CD002911.

PMID: 32364251 PMC: 7197139. DOI: 10.1002/14651858.CD002911.pub3.

Oral desmopressin in nocturia with benign prostatic hyperplasia: A systematic review of the literature.

Taha D, Aboumarzouk O, Shokeir A Arab J Urol. 2018; 16(4):404-410.

PMID: 30534439 PMC: 6277262. DOI: 10.1016/j.aju.2018.06.007.

Systematic Review and Meta-analysis of Alarm versus Desmopressin Therapy for Pediatric Monosymptomatic Enuresis.

Peng C, Yang S, Austin P, Chang S Sci Rep. 2018; 8(1):16755.

PMID: 30425276 PMC: 6233184. DOI: 10.1038/s41598-018-34935-1.

Nocturnal Enuresis in India: Are We Diagnosing and Managing Correctly?.

Reddy N, Malve H, Nerli R, Venkatesh P, Agarwal I, Rege V Indian J Nephrol. 2017; 27(6):417-426.

PMID: 29217876 PMC: 5704404. DOI: 10.4103/ijn.IJN_288_16.

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