Oral 'hydrogen Water' Induces Neuroprotective Ghrelin Secretion in Mice

Overview

Journal Sci Rep

Specialty Science

Date 2013 Nov 21

PMID 24253616

Citations 30

Authors

Akio Matsumoto

Megumi Yamafuji

Tomoko Tachibana

Yusaku Nakabeppu

Mami Noda

Haruaki Nakaya

Affiliations

Soon will be listed here.

Abstract

The therapeutic potential of molecular hydrogen (H₂) is emerging in a number of human diseases and in their animal models, including in particular Parkinson's disease (PD). H₂ supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H₂ supplementation does not result in detectable changes in striatal H₂ levels, indicating an indirect effect. Here we show that H₂ supplementation increases gastric expression of mRNA encoding ghrelin, a growth hormone secretagogue, and ghrelin secretion, which are antagonized by the β1-adrenoceptor blocker, atenolol. Strikingly, the neuroprotective effect of H₂ water was abolished by either administration of the ghrelin receptor-antagonist, D-Lys(3) GHRP-6, or atenolol. Thus, the neuroprotective effect of H₂ in PD is mediated by enhanced production of ghrelin. Our findings point to potential, novel strategies for ameliorating pathophysiology in which a protective effect of H₂ supplementation has been demonstrated.

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