Venturicidin C, a New 20-membered Macrolide Produced by Streptomyces Sp. TS-2-2

Overview

Journal J Antibiot (Tokyo)

Specialties Infectious Diseases
Pharmacology

Date 2013 Nov 21

PMID 24252813

Citations 21

Authors

Khaled A Shaaban

Shanteri Singh

Sherif I Elshahawi

Xiachang Wang

Larissa V Ponomareva

Manjula Sunkara

Gregory C Copley

James C Hower

Andrew J Morris

Madan K Kharel

Jon S Thorson

Affiliations

Soon will be listed here.

Abstract

Venturicidin C (1), a new 20-membered macrolide along with the known venturicidins A (2) and B (3) were isolated from the crude extract of the Appalachian bacterial strain Streptomyces sp. TS-2-2. Additionally, nine other known compounds namely nocardamine, dehydroxynocardamine, desmethylenylnocardamine, ferrioxamine E, adenosine, riboflavin, cyclo(D)-trans-4-OH-Pro-(D)-Phe, cyclo(D)-Pro-(D)-Phe and N-(2-phenylethyl)-acetamide were also isolated and identified. The structure of the new macrolide 1 was elucidated by the cumulative analyses of NMR spectroscopy and HR-MS data. Complete NMR assignments for the known venturicidins A (2) and B (3) are also provided, for the first time, in this report. Venturicidins A-C did not inhibit the proliferation of A549 lung cancer cell line but all displayed potent antifungal activity.

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