Is Serum Vitamin D Levels Associated with Disability in Patients with Newly Diagnosed Multiple Sclerosis?

Overview

Journal Iran J Neurol

Publisher Tehran University of Medical Sciences

Date 2013 Nov 20

PMID 24250900

Citations 4

Authors

Hamidreza Hatamian

Elham Bidabadi

Seyed Mohammad Seyed Saadat

Niloufar Seyed Saadat

Ehsan Kazemnezhad

Hamed Ramezani

Babak Bakhshayesh

Affiliations

Soon will be listed here.

Abstract

Background: Although the precise etiology of multiple sclerosis (MS) is unknown, it seems that both genetic and environmental factors are important. Recent studies suggest that low serum vitamin D levels are important environmental factor in MS. The aim of this study was to compare the serum levels of vitamin D between MS patients and healthy subjects, and to determine its association with disability in MS patients.

Methods: In this cross-sectional study, a total of 52 patients with MS were randomly recruited and matched for age and sex with 52 healthy subjects. Demographic characteristics and serum vitamin D levels for both groups, as well as duration of disease Expanded Disability Status Scale (EDSS) for MS patients were evaluated. Statistical analysis was performed by independent samples t-test and multiple linear regression analysis.

Results: The mean serum vitamin D levels were 26.5 ± 16.3 ng/ml in MS patients vs. 37.1 ±19.7 in healthy subjects (P = 0.003). A linear regression analysis showed no significant association between vitamin D levels and EDSS score of patients with MS (P = 0.345), after adjusting for the covariates.

Conclusion: Our findings did not suggest a protective association for serum vitamin D levels against disability in MS patients.

Citing Articles

Assessment of Biochemical and Densitometric Markers of Calcium-Phosphate Metabolism in the Groups of Patients with Multiple Sclerosis Selected due to the Serum Level of Vitamin D.

Niedziela N, Pierzchala K, Zalejska-Fiolka J, Niedziela J, Romuk E, Torbus-Paluszczak M Biomed Res Int. 2018; 2018:9329123.

PMID: 30211230 PMC: 6126066. DOI: 10.1155/2018/9329123.

Vitamin D and Neurological Diseases: An Endocrine View.

Di Somma C, Scarano E, Barrea L, Zhukouskaya V, Savastano S, Mele C Int J Mol Sci. 2017; 18(11).

PMID: 29160835 PMC: 5713448. DOI: 10.3390/ijms18112482.

Serum 25(OH) Vitamin D levels is not associated with disability in multiple sclerosis patients: A case-control study.

Nikanfar M, Taheri-Aghdam A, Yazdani M, Shaafi S, Masoudian N, Akbari H Iran J Neurol. 2015; 14(1):17-21.

PMID: 25874052 PMC: 4395802.

Multiple sclerosis and pregnancy; What a neurologist may be asked for?.

Siroos B, Harirchian M Iran J Neurol. 2014; 13(2):57-63.

PMID: 25295147 PMC: 4187331.

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