C1q Binding to Dengue Virus Decreases Levels of Infection and Inflammatory Molecules Transcription in THP-1 Cells

Overview

Journal Virus Res

Specialty Microbiology

Date 2013 Nov 20

PMID 24246304

Citations 12

Authors

Bruno Douradinha

Sean P McBurney

Klecia M Soares de Melo

Amanda P Smith

Neel K Krishna

Simon M Barratt-Boyes

Jared D Evans

Eduardo J M Nascimento

Ernesto T A Marques Jr

Affiliations

Soon will be listed here.

Abstract

Dengue virus infection elicits a spectrum of clinical presentations ranging from asymptomatic to severe disease. The mechanisms leading to severe dengue are not known, however it has been reported that the complement system is hyper-activated in severe dengue. Screening of complement proteins demonstrated that C1q, a pattern recognition molecule, can bind directly to dengue virus envelope protein and to whole dengue virus serotype 2. Incubation of dengue virus serotype 2 with C1q prior to infection of THP-1 cells led to decreased virus infectivity and modulation of mRNA expression of immunoregulatory molecules suggesting reduced inflammatory responses.

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