Left Ventricular Pressure Gating in Ovine Cardiac Studies: a Software-based Method

Overview

Journal J Biomech Eng

Publisher American Society of Mechanical Engineers

Date 2013 Nov 16

PMID 24231818

Authors

Gabriel Acevedo-Bolton

Takamaro Suzuki

Deepak Malhotra

Zhihong Zhang

Arthur W Wallace

Julius M Guccione

David A Saloner

Mark B Ratcliffe

Affiliations

Soon will be listed here.

Abstract

Cardiac imaging using magnetic resonance requires a gating signal in order to compensate for motion. Human patients are routinely scanned using an electrocardiogram (ECG) as a gating signal during imaging. However, we found that in sheep the ECG is not a reliable method for gating. We developed a software based method that allowed us to use the left ventricular pressure (LVP) as a reliable gating signal. By taking the time derivative of the LVP (dP/dt), we were able to start imaging at both end-diastole for systolic phase images, and end-systole for diastolic phase images. We also used MR tissue tagging to calculate 3D strain information during diastole. Using the LVP in combination with our digital circuit provided a reliable and time efficient method for ovine cardiac imaging. Unlike the ECG signal the left ventricular pressure was a clean signal and allowed for accurate, nondelay based triggering during systole and diastole.

References

Fischer S, McKinnon G, Maier S, Boesiger P . Improved myocardial tagging contrast. Magn Reson Med. 1993; 30(2):191-200. DOI: 10.1002/mrm.1910300207. View

BEISCHER D, KNEPTON Jr J . INFLUENCE OF STRONG MAGNETIC FIELDS ON THE ELECTROCARDIOGRAM OF SQUIRREL MONKEYS (SAIMIRI SCIUREUS). Aerosp Med. 1964; 35:939-44. View

Rutz A, Ryf S, Plein S, Boesiger P, Kozerke S . Accelerated whole-heart 3D CSPAMM for myocardial motion quantification. Magn Reson Med. 2008; 59(4):755-63. DOI: 10.1002/mrm.21363. View

Guccione J, Walker J, Beitler J, Moonly S, Zhang P, Guttman M . The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study. J Thorac Cardiovasc Surg. 2006; 131(3):579-586.e3. PMC: 1482534. DOI: 10.1016/j.jtcvs.2005.07.065. View

Axel L, Dougherty L . MR imaging of motion with spatial modulation of magnetization. Radiology. 1989; 171(3):841-5. DOI: 10.1148/radiology.171.3.2717762. View

Pirolo J, Branham B, Creswell L, Perman W, Vannier M, Pasque M . Pressure-gated acquisition of cardiac MR images. Radiology. 1992; 183(2):487-92. DOI: 10.1148/radiology.183.2.1561355. View

MOULTON M, Creswell L, Downing S, Actis R, Szabo B, Pasque M . Myocardial material property determination in the in vivo heart using magnetic resonance imaging. Int J Card Imaging. 1996; 12(3):153-67. DOI: 10.1007/BF01806218. View

Zerhouni E, Parish D, Rogers W, Yang A, Shapiro E . Human heart: tagging with MR imaging--a method for noninvasive assessment of myocardial motion. Radiology. 1988; 169(1):59-63. DOI: 10.1148/radiology.169.1.3420283. View

Fischer S, Wickline S, Lorenz C . Novel real-time R-wave detection algorithm based on the vectorcardiogram for accurate gated magnetic resonance acquisitions. Magn Reson Med. 1999; 42(2):361-70. DOI: 10.1002/(sici)1522-2594(199908)42:2<361::aid-mrm18>3.0.co;2-9. View

10.

Ozturk C, McVeigh E . Four-dimensional B-spline based motion analysis of tagged MR images: introduction and in vivo validation. Phys Med Biol. 2000; 45(6):1683-702. PMC: 2041909. DOI: 10.1088/0031-9155/45/6/319. View

11.

Togawa T, Okai O, Oshima M . Observation of blood flow E.M.F. in externally applied strong magnetic field by surface electrodes. Med Biol Eng. 1967; 5(2):169-70. DOI: 10.1007/BF02474505. View

12.

Guttman M, Zerhouni E, McVeigh E . Analysis of Cardiac Function from MR Images. IEEE Comput Graph Appl. 1997; 17(1):30-38. PMC: 2396596. DOI: 10.1109/38.576854. View

13.

Zhang P, Guccione J, Nicholas S, Walker J, Crawford P, Shamal A . Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep. J Thorac Cardiovasc Surg. 2007; 134(4):1017-24. PMC: 2615826. DOI: 10.1016/j.jtcvs.2007.03.060. View