» Articles » PMID: 24229668

Cross-sectional Association of Serum C-reactive Protein and Uric Acid with Albuminuria in Chinese Type 2 Diabetic Patients

Overview
Specialty General Medicine
Date 2013 Nov 16
PMID 24229668
Citations 3
Authors
Affiliations
Soon will be listed here.
Abstract

Background: Evidences show that subclinical chronic inflammation is involved in the pathogenesis of diabetic nephropathy. The aim of this study was to examine the relationship between serum C-reactive protein (CRP), serum uric acid, and albuminuria in Chinese type 2 diabetic patients.

Methods: A total of 1162 type 2 diabetic patients were recruited. All participants had relevant clinical and laboratory measurements. CRP was measured using a particle enhanced immunoturbidimetric assay.

Results: In the multiple linear regression model, natural log-transformed CRP (lnCRP) and uric acid were independent predictors of natural log-transformed urinary albumin to creatinine ratio (lnACR) (β = 0.18, 95% CI 0.10-0.27, P < 0.001 and β = 0.18, 95% CI 0.09-0.27, P < 0.001). The interaction of lnCRP with uric acid was also associated with lnACR (β = 0.04, 95% CI 0.02-0.06, P < 0.001). In the full-adjusted logistic regression model, the OR for albuminuria of the patients in the third tertile levels of CRP and uric acid was 3.94 compared with patients in the first tertile levels of CRP and uric acid (95% CI 1.73-8.94, P < 0.001).

Conclusions: Elevated serum CRP and increased serum uric acid level were associated with albuminuria in Chinese type 2 diabetic patients. Moreover, CRP and uric acid had an interactive effect on albuminuria.

Citing Articles

Association between serum uric acid and depressive symptoms stratified by low-grade inflammation status.

Rhee S, Lee H, Ahn Y Sci Rep. 2021; 11(1):20405.

PMID: 34650110 PMC: 8516956. DOI: 10.1038/s41598-021-99312-x.


Association of serum uric acid with nephropathy in Iranian type 2 diabetic patients.

Razi F, Nasli-Esfahani E, Bandarian F J Diabetes Metab Disord. 2018; 17(1):71-75.

PMID: 30288387 PMC: 6154522. DOI: 10.1007/s40200-018-0340-z.


Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population.

Sun M, Zhang L, Chen S, Liu X, Shao X, Zou H Int J Environ Res Public Health. 2015; 12(7):8228-42.

PMID: 26193292 PMC: 4515719. DOI: 10.3390/ijerph120708228.