The Development of Thought Problems: a Longitudinal Family Risk Study of Offspring of Bipolar, Unipolar, and Well Parents

Overview

Journal Dev Psychopathol

Publisher Cambridge University Press

Specialties Psychiatry
Psychology

Date 2013 Nov 16

PMID 24229550

Citations 1

Authors

Bonnie Klimes-Dougan

Christopher David Desjardins

Matthew G James

Angela J Narayan

Jeffrey D Long

Kathryn R Cullen

Philip W Gold

Pedro E Martinez

Affiliations

Soon will be listed here.

Abstract

There is growing evidence that many offspring of parents with bipolar disorder (BD) will develop moderate to severe forms of psychopathology during childhood and adolescence, including thought problems. The purpose of this study was to evaluate the developmental progression of thought problems within the context of a family risk study. Repeated assessments of thought problems, spanning approximately 15 years, were conducted in offspring (N = 192 from 98 families) of parents diagnosed with BD (O-BD), unipolar depression (O-UNI), or no significant psychiatric or medical problems (O-WELL). Survival analysis showed that the O-BD group had the greatest estimated probability of developing thought problems over time, followed by O-UNI, and then O-WELL and O-BD exhibiting higher levels of persistence than O-WELL. Parent-reported thought problems in childhood and adolescence predicted a range of problems in young adulthood. Disturbances in reality testing and other atypical behaviors are likely to disrupt progression through important developmental periods and to associate with poor outcomes. These findings are likely relevant to preventing the occurrence or progression of problems in offspring of bipolar parents. The study of thought problems across development represents an important area of continued research in children at risk for development of affective disorders.

Citing Articles

Disturbances in reality testing as markers of risk in offspring of parents with bipolar disorder: a systematic review from a developmental psychopathology perspective.

Narayan A, Allen T, Cullen K, Klimes-Dougan B Bipolar Disord. 2013; 15(7):723-40.

PMID: 24034419 PMC: 3943590. DOI: 10.1111/bdi.12115.

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