Retest Imaging of [11C]NOP-1A Binding to Nociceptin/orphanin FQ Peptide (NOP) Receptors in the Brain of Healthy Humans

Overview

Journal Neuroimage

Specialty Radiology

Date 2013 Nov 15

PMID 24225488

Citations 17

Authors

Talakad G Lohith

Sami S Zoghbi

Cheryl L Morse

Maria D Ferraris Araneta

Vanessa N Barth

Nancy A Goebl

Johannes T Tauscher

Victor W Pike

Robert B Innis

Masahiro Fujita

Affiliations

Soon will be listed here.

Abstract

[(11)C]NOP-1A is a novel high-affinity PET ligand for imaging nociceptin/orphanin FQ peptide (NOP) receptors. Here, we report reproducibility and reliability measures of binding parameter estimates for [(11)C]NOP-1A binding in the brain of healthy humans. After intravenous injection of [(11)C]NOP-1A, PET scans were conducted twice on eleven healthy volunteers on the same (10/11 subjects) or different (1/11 subjects) days. Subjects underwent serial sampling of radial arterial blood to measure parent radioligand concentrations. Distribution volume (VT; a measure of receptor density) was determined by compartmental (one- and two-tissue) modeling in large regions and by simpler regression methods (graphical Logan and bilinear MA1) in both large regions and voxel data. Retest variability and intraclass correlation coefficient (ICC) of VT were determined as measures of reproducibility and reliability respectively. Regional [(11)C]NOP-1A uptake in the brain was high, with a peak radioactivity concentration of 4-7 SUV (standardized uptake value) and a rank order of putamen>cingulate cortex>cerebellum. Brain time-activity curves fitted well in 10 of 11 subjects by unconstrained two-tissue compartmental model. The retest variability of VT was moderately good across brain regions except cerebellum, and was similar across different modeling methods, averaging 12% for large regions and 14% for voxel-based methods. The retest reliability of VT was also moderately good in most brain regions, except thalamus and cerebellum, and was similar across different modeling methods averaging 0.46 for large regions and 0.48 for voxels having gray matter probability >20%. The lowest retest variability and highest retest reliability of VT were achieved by compartmental modeling for large regions, and by the parametric Logan method for voxel-based methods. Moderately good reproducibility and reliability measures of VT for [(11)C]NOP-1A make it a useful PET ligand for comparing NOP receptor binding between different subject groups or under different conditions in the same subject.

Citing Articles

The opioid system in depression.

Jelen L, Stone J, Young A, Mehta M Neurosci Biobehav Rev. 2022; 140:104800.

PMID: 35914624 PMC: 10166717. DOI: 10.1016/j.neubiorev.2022.104800.

Copper-Mediated Radiocyanation of Unprotected Amino Acids and Peptides.

Sharninghausen L, Preshlock S, Joy S, Horikawa M, Shao X, Winton W J Am Chem Soc. 2022; 144(16):7422-7429.

PMID: 35437016 PMC: 9887455. DOI: 10.1021/jacs.2c01959.

Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse.

Kiguchi N, Ding H, Ko M J Neurosci Res. 2020; 100(1):191-202.

PMID: 32255240 PMC: 7573817. DOI: 10.1002/jnr.24624.

A Survey of Molecular Imaging of Opioid Receptors.

Cumming P, Marton J, Lilius T, Olberg D, Rominger A Molecules. 2019; 24(22).

PMID: 31752279 PMC: 6891617. DOI: 10.3390/molecules24224190.

Acute Elevations in Cortisol Increase the In Vivo Binding of [C]NOP-1A to Nociceptin Receptors: A Novel Imaging Paradigm to Study the Interaction Between Stress- and Antistress-Regulating Neuropeptides.

Flanigan M, Tollefson S, Himes M, Jordan R, Roach K, Stoughton C Biol Psychiatry. 2019; 87(6):570-576.

PMID: 31706582 PMC: 7035995. DOI: 10.1016/j.biopsych.2019.09.013.

References

Hostetler E, Sanabria-Bohorquez S, Eng W, Joshi A, Patel S, Gibson R . Evaluation of [¹⁸F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human. Neuroimage. 2012; 68:1-10. DOI: 10.1016/j.neuroimage.2012.11.053. View

Lohith T, Zoghbi S, Morse C, Araneta M, Barth V, Goebl N . Brain and whole-body imaging of nociceptin/orphanin FQ peptide receptor in humans using the PET ligand 11C-NOP-1A. J Nucl Med. 2012; 53(3):385-92. PMC: 3835399. DOI: 10.2967/jnumed.111.097162. View

Abi-Dargham A, Laruelle M, Krystal J, DSouza C, Zoghbi S, Baldwin R . No evidence of altered in vivo benzodiazepine receptor binding in schizophrenia. Neuropsychopharmacology. 1999; 20(6):650-61. DOI: 10.1016/S0893-133X(98)00107-9. View

Kimura Y, Fujita M, Hong J, Lohith T, Gladding R, Zoghbi S . Brain and whole-body imaging in rhesus monkeys of 11C-NOP-1A, a promising PET radioligand for nociceptin/orphanin FQ peptide receptors. J Nucl Med. 2011; 52(10):1638-45. PMC: 3216483. DOI: 10.2967/jnumed.111.091181. View

Jucaite A, Cselenyi Z, Arvidsson A, Ahlberg G, Julin P, Varnas K . Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects. EJNMMI Res. 2012; 2:15. PMC: 3350394. DOI: 10.1186/2191-219X-2-15. View

Terry G, Liow J, Zoghbi S, Hirvonen J, Farris A, Lerner A . Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand. Neuroimage. 2009; 48(2):362-70. PMC: 2730982. DOI: 10.1016/j.neuroimage.2009.06.059. View

Ichise M, Toyama H, Innis R, Carson R . Strategies to improve neuroreceptor parameter estimation by linear regression analysis. J Cereb Blood Flow Metab. 2002; 22(10):1271-81. DOI: 10.1097/01.WCB.0000038000.34930.4E. View

Kim J, Ichise M, Sangare J, Innis R . PET imaging of serotonin transporters with [11C]DASB: test-retest reproducibility using a multilinear reference tissue parametric imaging method. J Nucl Med. 2006; 47(2):208-14. View

Slifstein M, Laruelle M . Effects of statistical noise on graphic analysis of PET neuroreceptor studies. J Nucl Med. 2001; 41(12):2083-8. View

10.

Hirvonen J, Goodwin R, Li C, Terry G, Zoghbi S, Morse C . Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Mol Psychiatry. 2011; 17(6):642-9. PMC: 3223558. DOI: 10.1038/mp.2011.82. View

11.

Pike V, Rash K, Chen Z, Pedregal C, Statnick M, Kimura Y . Synthesis and evaluation of radioligands for imaging brain nociceptin/orphanin FQ peptide (NOP) receptors with positron emission tomography. J Med Chem. 2011; 54(8):2687-700. PMC: 3081360. DOI: 10.1021/jm101487v. View

12.

Deschwanden A, Karolewicz B, Feyissa A, Treyer V, Ametamey S, Johayem A . Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study. Am J Psychiatry. 2011; 168(7):727-34. PMC: 3129412. DOI: 10.1176/appi.ajp.2011.09111607. View

13.

Zanotti-Fregonara P, Zoghbi S, Liow J, Luong E, Boellaard R, Gladding R . Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image-derived input function. Neuroimage. 2010; 54(3):1903-9. PMC: 3026385. DOI: 10.1016/j.neuroimage.2010.10.064. View

14.

Hawkins R, Phelps M, Huang S . Effects of temporal sampling, glucose metabolic rates, and disruptions of the blood-brain barrier on the FDG model with and without a vascular compartment: studies in human brain tumors with PET. J Cereb Blood Flow Metab. 1986; 6(2):170-83. DOI: 10.1038/jcbfm.1986.30. View

15.

Landis J, Koch G . The measurement of observer agreement for categorical data. Biometrics. 1977; 33(1):159-74. View

16.

Laruelle M . Modelling: when and why?. Eur J Nucl Med. 1999; 26(6):571-2. DOI: 10.1007/s002590050423. View

17.

Gandelman M, Baldwin R, Zoghbi S, Zea-Ponce Y, Innis R . Evaluation of ultrafiltration for the free-fraction determination of single photon emission computed tomography (SPECT) radiotracers: beta-CIT, IBF, and iomazenil. J Pharm Sci. 1994; 83(7):1014-9. DOI: 10.1002/jps.2600830718. View

18.

DeLorenzo C, Dileep Kumar J, Mann J, Parsey R . In vivo variation in metabotropic glutamate receptor subtype 5 binding using positron emission tomography and [11C]ABP688. J Cereb Blood Flow Metab. 2011; 31(11):2169-80. PMC: 3210337. DOI: 10.1038/jcbfm.2011.105. View

19.

Delaney G, Dawe K, Hogan R, Hunjan T, Roper J, Hazell G . Role of nociceptin/orphanin FQ and NOP receptors in the response to acute and repeated restraint stress in rats. J Neuroendocrinol. 2012; 24(12):1527-41. PMC: 3546383. DOI: 10.1111/j.1365-2826.2012.02361.x. View

20.

Hirvonen J, Aalto S, Hagelberg N, Maksimow A, Ingman K, Oikonen V . Measurement of central mu-opioid receptor binding in vivo with PET and [11C]carfentanil: a test-retest study in healthy subjects. Eur J Nucl Med Mol Imaging. 2008; 36(2):275-86. DOI: 10.1007/s00259-008-0935-6. View