A Phase 2 Study of HQK-1001, an Oral Fetal Haemoglobin Inducer, in β-thalassaemia Intermedia

Overview

Journal Br J Haematol

Specialty Hematology

Date 2013 Nov 15

PMID 24224649

Citations 4

Authors

Adlette Inati

Mario Kahale

Susan P Perrine

David H K Chui

Ali T Taher

Suzanne Koussa

Therese Abi Nasr

Hussein A Abbas

Richard G Ghalie

Affiliations

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Natural Remedies for the Treatment of Beta-Thalassemia and Sickle Cell Anemia-Current Status and Perspectives in Fetal Hemoglobin Reactivation.

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Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells.

Chou Y, Chen R, Lai Z, Song J, Chao Y, Shen C Mol Cell Biol. 2015; 35(14):2541-53.

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References

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Fucharoen S, Inati A, Siritanaratku N, Thein S, Wargin W, Koussa S . A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia. Br J Haematol. 2013; 161(4):587-93. PMC: 3970579. DOI: 10.1111/bjh.12304. View

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Thein S, Menzel S, Lathrop M, Garner C . Control of fetal hemoglobin: new insights emerging from genomics and clinical implications. Hum Mol Genet. 2009; 18(R2):R216-23. PMC: 2758709. DOI: 10.1093/hmg/ddp401. View

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