Identification and Diversity of Killer Cell Ig-like Receptors in Aotus Vociferans, a New World Monkey

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Nov 14

PMID 24223188

Citations 4

Authors

Diego Garzon-Ospina

Carolina Lopez

Luis F Cadavid

Manuel E Patarroyo

Manuel A Patarroyo

Affiliations

Soon will be listed here.

Abstract

Previous BAC clone analysis of the Platyrrhini owl monkey KIRs have shown an unusual genetic structure in some loci. Therefore, cDNAs encoding KIR molecules from eleven Aotus vociferans monkeys were characterized here; ten putative KIR loci were found, some of which encoded atypical proteins such as KIR4DL and transcripts predicted to encode a D0+D1 configuration (AOTVOKIR2DL1*01v1) which appear to be unique in the Aotus genus. Furthermore, alternative splicing was found as a likely mechanism for producing activator receptors in A. vociferans species. KIR proteins from New World monkeys may be split into three new lineages according to domain by domain phylogenetic analysis. Although the A. vociferans KIR family displayed a high divergence among paralogous genes, individual loci were limited in their genetic polymorphism. Selection analysis showed that both constrained and rapid evolution may operate within the AvKIR family. The frequent alternative splicing (as a likely mechanism generating activator receptors), the presence of KIR4DL and KIR2DL1 (D0+D1) molecules and other data reported here suggest that the KIR family in Aotus has had a rapid evolution, independent from its Catarrhini counterparts.

Citing Articles

Rhesus Macaque Activating Killer Immunoglobulin-Like Receptors Associate With Fc Receptor Gamma (FCER1G) and Not With DAP12 Adaptor Proteins Resulting in Stabilized Expression and Enabling Signal Transduction.

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Igh locus structure and evolution in Platyrrhines: new insights from a genomic perspective.

Garzon-Ospina D, Buitrago S Immunogenetics. 2019; 72(3):165-179.

PMID: 31838542 DOI: 10.1007/s00251-019-01151-8.

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Co-evolution of MHC class I and variable NK cell receptors in placental mammals.

Guethlein L, Norman P, Hilton H, Parham P Immunol Rev. 2015; 267(1):259-82.

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