Fulminant Hepatitis Due to Father-to-Newborn Transmission of Herpes Simplex Virus Type 1
Overview
Affiliations
We describe a case of a severe neonatal infection by herpes simplex virus (HSV) type 1 acquired postnatally from his father. The delivery and the first days of life were normal. He developed liver failure and disseminated intravascular coagulation when he was 19 days old. He was treated with intravenous acyclovir and the outcome was favorable. This case underlines that prevention of post-natal transmission of HSV merits to be considered in educational pregnancy programs directed at mothers and fathers.
The immunogenetic basis of severe herpes simplex infections in neonates and children: a review.
Tucker M, Kalamvoki M, Tilak K, Raje N, Sampath V Pediatr Res. 2025; .
PMID: 39827257 DOI: 10.1038/s41390-025-03830-7.
Neonatal herpes: case series in two obstetric centres over a 10-year period (2013-2023), France.
Bouthry E, Portet-Sulla V, Bouokazi M, Perillaud-Dubois C, Javaugue F, Jule L Eur J Pediatr. 2024; 183(8):3183-3191.
PMID: 38678161 DOI: 10.1007/s00431-024-05581-9.
Kidszun A, Bruns A, Schreiner D, Tippmann S, Winter J, Pokora R Arch Dis Child Fetal Neonatal Ed. 2021; 107(2):188-192.
PMID: 34257101 PMC: 8867279. DOI: 10.1136/archdischild-2021-321940.