The Perinucleolar Compartment: RNA Metabolism and Cancer

Overview

Journal Cancer Treat Res

Publisher Springer

Specialties Oncology
Pharmacology

Date 2013 Nov 14

PMID 24222357

Citations 11

Authors

John T Norton

Sui Huang

Affiliations

Soon will be listed here.

Abstract

The perinucleolar compartment (PNC) is a nuclear substructure associated with, but structurally distinct from, the nucleolus. The PNC contains several RNA processing proteins and several RNA pol III transcripts, which form novel complexes. As determined by cell culture experiments and human tumor samples, the PNC forms exclusively in cancer cells and the percentage of cancer cells in a population that have one or more PNCs directly correlates with the malignancy of that population of cells. Therefore, the PNC is being developed as a prognostic marker for several malignancies. PNC elimination in cancer cells has proven to be a useful as screening method to discover probe compounds used to elucidate PNC biology and to discover compounds with the potential to be developed as minimally toxic anti-cancer drugs.

Citing Articles

Small Molecule with Big Impact: Metarrestin Targets the Perinucleolar Compartment in Cancer Metastasis.

Kashyap V, Sharma B, Pandey D, Singh A, Peasah-Darkwah G, Singh B Cells. 2025; 13(24.

PMID: 39768145 PMC: 11674295. DOI: 10.3390/cells13242053.

RAVER1 hinders lethal EMT and modulates miR/RISC activity by the control of alternative splicing.

Wedler A, Bley N, Glass M, Muller S, Rausch A, Lederer M Nucleic Acids Res. 2024; 52(7):3971-3988.

PMID: 38300787 PMC: 11039986. DOI: 10.1093/nar/gkae046.

The perinucleolar compartment: structure, function, and utility in anti-cancer drug development.

Makeyev E, Huang S Nucleus. 2024; 15(1):2306777.

PMID: 38281066 PMC: 10824145. DOI: 10.1080/19491034.2024.2306777.

Perinucleolar Compartment (PNC) Prevalence as an Independent Prognostic Factor in Pediatric Ewing Sarcoma: A Multi-Institutional Study.

Gonzalez E, Ahmed A, McCarthy L, Chastain K, Habeebu S, Zapata-Tarres M Cancers (Basel). 2023; 15(8).

PMID: 37190159 PMC: 10136508. DOI: 10.3390/cancers15082230.

LncRNAs divide and rule: The master regulators of phase separation.

Somasundaram K, Gupta B, Jain N, Jana S Front Genet. 2022; 13:930792.

PMID: 36035193 PMC: 9399341. DOI: 10.3389/fgene.2022.930792.

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