Pesticides, Gene Polymorphisms, and Bladder Cancer Among Egyptian Agricultural Workers

Overview

Journal Arch Environ Occup Health

Specialties Environmental Health
Occupational Medicine

Date 2013 Nov 14

PMID 24219772

Citations 20

Authors

Sania Amr

Rebecca Dawson

Doaa A Saleh

Laurence S Magder

Diane Marie St George

Mai El-Daly

Katherine Squibb

Nabiel N Mikhail

Mohamed Abdel-Hamid

Hussein Khaled

Christopher A Loffredo

Affiliations

Soon will be listed here.

Abstract

Nad(p)h: quinone oxidoreductase I (NQO1) and superoxide dismutase 2 (SOD2), and urinary bladder cancer risk among male agricultural workers in Egypt. Logistic regression was used to analyze data from a multicenter case-control study and estimate adjusted odds ratio (OR) and 95% confidence interval (CI). Exposure to pesticides was associated with increased bladder cancer risk (odds ratio (95% confidence interval): 1.68 (1.23-2.29)) in a dose-dependent manner. The association was slightly stronger for urothelial (1.79 (1.25-2.56)) than for squamous cell (1.55 (1.03-2.31)), and among participants with combined genotypes for low NQO1 and high SOD2 (2.14 (1.19-3.85)) activities as compared with those with high NQO1 and low SOD2 genotypes (1.53 (0.73-3.25)). In conclusion, among male agricultural workers in Egypt, pesticide exposure is associated with bladder cancer risk and possibly modulated by genetic polymorphism.

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