The Role of Spacers on the Self-assembly of DNA Aptamer-amphiphiles into Micelles and Nanotapes

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2013 Nov 13

PMID 24216758

Citations 5

Authors

Timothy R Pearce

Brett Waybrant

Efrosini Kokkoli

Affiliations

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Abstract

The self-assembly of single-stranded DNA (ssDNA) aptamer-amphiphiles was influenced by the choice of spacer used to link the hydrophobic tail and aptamer headgroup. Aptamer-amphiphiles without spacers or with hydrophilic spacers formed globular micelles while amphiphiles with hydrophobic spacers formed bilayer nanotapes, which are the first such structures formed by DNA-amphiphiles.

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