Shrinkage of Pegylated and Non-pegylated Liposomes in Serum

Overview

Journal Colloids Surf B Biointerfaces

Publisher Elsevier

Specialty Chemistry

Date 2013 Nov 13

PMID 24216620

Citations 35

Authors

Joy Wolfram

Krishna Suri

Yong Yang

Jianliang Shen

Christian Celia

Massimo Fresta

Yuliang Zhao

Haifa Shen

Mauro Ferrari

Affiliations

Soon will be listed here.

Abstract

An essential requisite for the design of nanodelivery systems is the ability to characterize the size, homogeneity and zeta potential of nanoparticles. Such properties can be tailored in order to create the most efficient drug delivery platforms. An important question is whether these characteristics change upon systemic injection. Here, we have studied the behavior of phosphatidylcholine/cholesterol liposomes exposed to serum proteins. The results reveal a serum-induced reduction in the size and homogeneity of both pegylated and non-pegylated liposomes, implicating the possible role of osmotic forces. In addition, changes to zeta-potential were observed upon exposing liposomes to serum. The liposomes with polyethylene glycol expressed different characteristics than their non-polymeric counterparts, suggesting the potential formation of a denser protein corona around the non-pegylated liposomes.

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References

Kim H, Andrieux K, Delomenie C, Chacun H, Appel M, Desmaele D . Analysis of plasma protein adsorption onto PEGylated nanoparticles by complementary methods: 2-DE, CE and Protein Lab-on-chip system. Electrophoresis. 2007; 28(13):2252-61. DOI: 10.1002/elps.200600694. View

Lundqvist M, Stigler J, Elia G, Lynch I, Cedervall T, Dawson K . Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. Proc Natl Acad Sci U S A. 2008; 105(38):14265-70. PMC: 2567179. DOI: 10.1073/pnas.0805135105. View

Zhang F, Kang E, Neoh K, Wang P, Tan K . Surface modification of stainless steel by grafting of poly(ethylene glycol) for reduction in protein adsorption. Biomaterials. 2001; 22(12):1541-8. DOI: 10.1016/s0142-9612(00)00310-0. View

Hupfeld S, Moen H, Ausbacher D, Haas H, Brandl M . Liposome fractionation and size analysis by asymmetrical flow field-flow fractionation/multi-angle light scattering: influence of ionic strength and osmotic pressure of the carrier liquid. Chem Phys Lipids. 2009; 163(2):141-7. DOI: 10.1016/j.chemphyslip.2009.10.009. View

Koudelka S, Turanek J . Liposomal paclitaxel formulations. J Control Release. 2012; 163(3):322-34. DOI: 10.1016/j.jconrel.2012.09.006. View

Zhang L, Gu F, Chan J, Wang A, Langer R, Farokhzad O . Nanoparticles in medicine: therapeutic applications and developments. Clin Pharmacol Ther. 2007; 83(5):761-9. DOI: 10.1038/sj.clpt.6100400. View

Sabin J, Prieto G, Ruso J, Hidalgo-Alvarez R, Sarmiento F . Size and stability of liposomes: a possible role of hydration and osmotic forces. Eur Phys J E Soft Matter. 2006; 20(4):401-8. DOI: 10.1140/epje/i2006-10029-9. View

Cabral H, Matsumoto Y, Mizuno K, Chen Q, Murakami M, Kimura M . Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol. 2011; 6(12):815-23. DOI: 10.1038/nnano.2011.166. View

Sen K, Mandal M . Second generation liposomal cancer therapeutics: transition from laboratory to clinic. Int J Pharm. 2013; 448(1):28-43. DOI: 10.1016/j.ijpharm.2013.03.006. View

10.

Allen T, Cullis P . Liposomal drug delivery systems: from concept to clinical applications. Adv Drug Deliv Rev. 2012; 65(1):36-48. DOI: 10.1016/j.addr.2012.09.037. View

11.

Tierney K, Block D, Longo M . Elasticity and phase behavior of DPPC membrane modulated by cholesterol, ergosterol, and ethanol. Biophys J. 2005; 89(4):2481-93. PMC: 1366747. DOI: 10.1529/biophysj.104.057943. View

12.

Salvati A, Pitek A, Monopoli M, Prapainop K, Bombelli F, Hristov D . Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface. Nat Nanotechnol. 2013; 8(2):137-43. DOI: 10.1038/nnano.2012.237. View

13.

Pencer J, White G, Hallett F . Osmotically induced shape changes of large unilamellar vesicles measured by dynamic light scattering. Biophys J. 2001; 81(5):2716-28. PMC: 1301738. DOI: 10.1016/S0006-3495(01)75914-0. View

14.

Chang H, Yeh M . Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy. Int J Nanomedicine. 2012; 7:49-60. PMC: 3260950. DOI: 10.2147/IJN.S26766. View

15.

Immordino M, Dosio F, Cattel L . Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. Int J Nanomedicine. 2007; 1(3):297-315. PMC: 2426795. View

16.

Mahon E, Salvati A, Bombelli F, Lynch I, Dawson K . Designing the nanoparticle-biomolecule interface for "targeting and therapeutic delivery". J Control Release. 2012; 161(2):164-74. DOI: 10.1016/j.jconrel.2012.04.009. View

17.

Wagner V, Dullaart A, Bock A, Zweck A . The emerging nanomedicine landscape. Nat Biotechnol. 2006; 24(10):1211-7. DOI: 10.1038/nbt1006-1211. View

18.

Monopoli M, Aberg C, Salvati A, Dawson K . Biomolecular coronas provide the biological identity of nanosized materials. Nat Nanotechnol. 2012; 7(12):779-86. DOI: 10.1038/nnano.2012.207. View

19.

Hamad I, Al-Hanbali O, Hunter A, Rutt K, Andresen T, Moghimi S . Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: implications for stealth nanoparticle engineering. ACS Nano. 2010; 4(11):6629-38. DOI: 10.1021/nn101990a. View

20.

Monopoli M, Walczyk D, Campbell A, Elia G, Lynch I, Bombelli F . Physical-chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles. J Am Chem Soc. 2011; 133(8):2525-34. DOI: 10.1021/ja107583h. View