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Lack of Detectable Oral Bioavailability of Plant MicroRNAs After Feeding in Mice

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Journal Nat Biotechnol
Specialty Biotechnology
Date 2013 Nov 12
PMID 24213763
Citations 131
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References
1.
Forbes D, Peppas N . Oral delivery of small RNA and DNA. J Control Release. 2012; 162(2):438-45. DOI: 10.1016/j.jconrel.2012.06.037. View

2.
Timmons L, Fire A . Specific interference by ingested dsRNA. Nature. 1998; 395(6705):854. DOI: 10.1038/27579. View

3.
Baum J, Bogaert T, Clinton W, Heck G, Feldmann P, Ilagan O . Control of coleopteran insect pests through RNA interference. Nat Biotechnol. 2007; 25(11):1322-6. DOI: 10.1038/nbt1359. View

4.
Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Y . Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res. 2011; 22(1):107-26. PMC: 3351925. DOI: 10.1038/cr.2011.158. View

5.
Munafo D, Robb G . Optimization of enzymatic reaction conditions for generating representative pools of cDNA from small RNA. RNA. 2010; 16(12):2537-52. PMC: 2995414. DOI: 10.1261/rna.2242610. View