Preclinical Cancer Chemoprevention Studies Using Animal Model of Inflammation-associated Colorectal Carcinogenesis

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2013 Nov 12

PMID 24213461

Citations 6

Authors

Takuji Tanaka

Affiliations

Soon will be listed here.

Abstract

Inflammation is involved in all stages of carcinogenesis. Inflammatory bowel disease, such as ulcerative colitis and Crohn's disease is a longstanding inflammatory disease of intestine with increased risk for colorectal cancer (CRC). Several molecular events involved in chronic inflammatory process are reported to contribute to multi-step carcinogenesis of CRC in the inflamed colon. They include over-production of free radicals, reactive oxygen and nitrogen species, up-regulation of inflammatory enzymes in arachidonic acid biosynthesis pathway, up-regulation of certain cytokines, and intestinal immune system dysfunction. In this article, firstly I briefly introduce our experimental animal models where colorectal neoplasms rapidly develop in the inflamed colorectum. Secondary, data on preclinical cancer chemoprevention studies of inflammation-associated colon carcinogenesis by morin, bezafibrate, and valproic acid, using this novel inflammation-related colorectal carcinogenesis model is described.

Citing Articles

Okada F, Izutsu R, Goto K, Osaki M Cancers (Basel). 2021; 13(4).

PMID: 33671768 PMC: 7926701. DOI: 10.3390/cancers13040921.

Anti-Oxidant, Pro-Oxidant and Anti-Inflammatory Effects of Unpolished Rice Relevant to Colorectal Cancer.

Suwannalert P, Payuhakrit W, Koomsang T Asian Pac J Cancer Prev. 2017; 17(12):5047-5056.

PMID: 28122433 PMC: 5454635. DOI: 10.22034/APJCP.2016.17.12.5047.

In vitro cytogenetic toxicity of bezafibrate in human peripheral blood lymphocytes.

Topaktas M, Kafkas N, Sadighazadi S, Istifli E Cytotechnology. 2017; 69(4):579-589.

PMID: 28097454 PMC: 5507839. DOI: 10.1007/s10616-017-0069-4.

The peroxisome proliferator-activated receptor (PPAR) α agonist fenofibrate suppresses chemically induced lung alveolar proliferative lesions in male obese hyperlipidemic mice.

Kuno T, Hata K, Takamatsu M, Hara A, Hirose Y, Takahashi S Int J Mol Sci. 2014; 15(5):9160-72.

PMID: 24857924 PMC: 4057781. DOI: 10.3390/ijms15059160.

Animal models and the tumor microenvironment: studies of tumor-host symbiosis.

Lindner D Semin Oncol. 2014; 41(2):146-55.

PMID: 24787289 PMC: 4008865. DOI: 10.1053/j.seminoncol.2014.02.004.

References

Eaden J, Abrams K, Mayberry J . The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001; 48(4):526-35. PMC: 1728259. DOI: 10.1136/gut.48.4.526. View

Kuendgen A, Schmid M, Schlenk R, Knipp S, Hildebrandt B, Steidl C . The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia. Cancer. 2005; 106(1):112-9. DOI: 10.1002/cncr.21552. View

Xiao S, Anderson S, Swanson C, Bahnemann R, Voss K, Stauber A . Activation of peroxisome proliferator-activated receptor alpha enhances apoptosis in the mouse liver. Toxicol Sci. 2006; 92(2):368-77. DOI: 10.1093/toxsci/kfl002. View

Thompson E . PPARgamma physiology and pathology in gastrointestinal epithelial cells. Mol Cells. 2007; 24(2):167-76. View

Bruce W, Wolever T, Giacca A . Mechanisms linking diet and colorectal cancer: the possible role of insulin resistance. Nutr Cancer. 2000; 37(1):19-26. DOI: 10.1207/S15327914NC3701_2. View

Wanczyk M, Roszczenko K, Marcinkiewicz K, Bojarczuk K, Kowara M, Winiarska M . HDACi--going through the mechanisms. Front Biosci (Landmark Ed). 2011; 16(1):340-59. DOI: 10.2741/3691. View

Cooper H, Murthy S, Shah R, Sedergran D . Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 1993; 69(2):238-49. View

Tenenbaum A, Motro M, Fisman E, Schwammenthal E, Adler Y, Goldenberg I . Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease. Circulation. 2004; 109(18):2197-202. DOI: 10.1161/01.CIR.0000126824.12785.B6. View

Mahlknecht U, Hoelzer D . Histone acetylation modifiers in the pathogenesis of malignant disease. Mol Med. 2000; 6(8):623-44. PMC: 1949974. View

10.

Galvez J, Coelho G, Crespo M, Cruz T, Rodriguez-Cabezas M, Concha A . Intestinal anti-inflammatory activity of morin on chronic experimental colitis in the rat. Aliment Pharmacol Ther. 2001; 15(12):2027-39. DOI: 10.1046/j.1365-2036.2001.01133.x. View

11.

Yamada Y, Hata K, Hirose Y, Hara A, Sugie S, Kuno T . Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice. Cancer Res. 2002; 62(22):6367-70. View

12.

Velayos F, Terdiman J, Walsh J . Effect of 5-aminosalicylate use on colorectal cancer and dysplasia risk: a systematic review and metaanalysis of observational studies. Am J Gastroenterol. 2005; 100(6):1345-53. DOI: 10.1111/j.1572-0241.2005.41442.x. View

13.

Cowey S, Hardy R . The metabolic syndrome: A high-risk state for cancer?. Am J Pathol. 2006; 169(5):1505-22. PMC: 1780220. DOI: 10.2353/ajpath.2006.051090. View

14.

Chavez-Blanco A, Segura-Pacheco B, Perez-Cardenas E, Taja-Chayeb L, Cetina L, Candelaria M . Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study. Mol Cancer. 2005; 4(1):22. PMC: 1198251. DOI: 10.1186/1476-4598-4-22. View

15.

Sarraf P, Mueller E, Jones D, KING F, DeAngelo D, Partridge J . Differentiation and reversal of malignant changes in colon cancer through PPARgamma. Nat Med. 1998; 4(9):1046-52. DOI: 10.1038/2030. View

16.

Takahashi M, Wakabayashi K . Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci. 2004; 95(6):475-80. PMC: 11158569. DOI: 10.1111/j.1349-7006.2004.tb03235.x. View

17.

Paz E, Garcia-Huidobro J, Ignatenko N . Polyamines in cancer. Adv Clin Chem. 2011; 54:45-70. DOI: 10.1016/b978-0-12-387025-4.00002-9. View

18.

Milutinovic S, DAlessio A, Detich N, Szyf M . Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. Carcinogenesis. 2006; 28(3):560-71. DOI: 10.1093/carcin/bgl167. View

19.

Fandy T, Shankar S, Ross D, Sausville E, Srivastava R . Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma. Neoplasia. 2005; 7(7):646-57. PMC: 1501425. DOI: 10.1593/neo.04655. View

20.

Kohno H, Suzuki R, Sugie S, Tanaka T . Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. Cancer Sci. 2005; 96(2):69-76. PMC: 11159258. DOI: 10.1111/j.1349-7006.2005.00020.x. View