Treatment Resistance Mechanisms of Malignant Glioma Tumor Stem Cells

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2013 Nov 12

PMID 24212632

Citations 10

Authors

Philip G R Schmalz

Michael J Shen

John K Park

Affiliations

Soon will be listed here.

Abstract

Malignant gliomas are highly lethal because of their resistance to conventional treatments. Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors. These tumor stem cells are more resistant to radiation and chemotherapies than their counterpart differentiated tumor cells and may underlie the persistence and recurrence of tumors following treatment. The various mechanisms by which tumor stem cells avoid or repair the damaging effects of cancer therapies are discussed.

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