Cathepsin D Coexists with Renin in the Secretory Granules of Juxtaglomerular Epithelioid Cells

Overview

Journal Histochemistry

Specialty Biochemistry

Date 1986 Jan 1

PMID 2420756

Citations 9

Authors

R TAUGNER

S Yokota

C P Buhrle

E HACKENTHAL

Affiliations

Soon will be listed here.

Abstract

Mature juxtaglomerular epithelioid cell secretory granules of the rat exhibit both renin- and cathepsin D-like immunoreactivity. On the basis of the coexistence with renin at a pH which, according to previous experiments, is probably in the range of that in lysosomes, cathepsin D is suggested to be involved in the regulation of the granular renin stores available for secretion.

Citing Articles

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The granular epithelioid cells in the kidney of the lemon sole (Pleuronectes microcephalus Donovani).

CHRISTENSEN J, TAUGNER R, Meyer D, Bohle A Cell Tissue Res. 1987; 249(1):137-43.

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The fate of prorenin during granulopoiesis in epithelioid cells. Immunocytochemical experiments with antisera against renin and different portions of the renin prosegment.

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Typical and atypical aspects of renin secretion from juxtaglomerular epithelioid cells.

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