Factors Associated with Breast Cancer in Puerto Rican Women

Overview

Journal J Epidemiol Glob Health

Publisher Springer

Date 2013 Nov 12

PMID 24206792

Citations 28

Authors

Luisa Morales

Carolina Alvarez-Garriga

Jaime Matta

Carmen Ortiz

Yeidyly Vergne

Wanda Vargas

Heidi Acosta

Jonathan Ramirez

Julyann Perez-Mayoral

Manuel Bayona

Affiliations

Soon will be listed here.

Abstract

Background: Breast cancer (BC) is the most common cancer afflicting Puerto Rican women and accounts for more cancer-related deaths in this population than any other cancer.

Methods: Demographic, anthropometric, family history, and lifestyle data, as well as DNA repair capacity (DRC), were compared in 465 BC cases and 661 controls. Crude and multiple logistic regression-derived adjusted odds ratios were used as indicators of the associations between BC and the variables under study.

Results: A low DRC level, aging (>61years), family history of BC, and low education level had statistically significant associations with increased BC risk. Endometriosis, full-term pregnancy at an earlier age, higher parity, hysterectomy before age 50, multivitamin and calcium intake, and longer duration of breastfeeding significantly decreased BC risk.

Conclusions: This study discusses the major risk factors for BC in Puerto Rico (PR). Because many of these findings represent modifiable risk factors, they can translate into public health initiatives to lower BC risk. In addition, the possibility of using DRC as a simple screening tool for BC risk is explored.

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