MicroRNAs in Cancer Cell Response to Ionizing Radiation

Overview

Journal Antioxid Redox Signal

Specialty Endocrinology

Date 2013 Nov 12

PMID 24206455

Citations 48

Authors

Jennifer R Czochor

Peter M Glazer

Affiliations

Soon will be listed here.

Abstract

Significance: microRNAs (miRNA) have been characterized as master regulators of the genome. As such, miRNAs are responsible for regulating almost every cellular pathway, including the DNA damage response (DDR) after ionizing radiation (IR). IR is a therapeutic tool that is used for the treatment of several types of cancer, yet the mechanism behind radiation response is not fully understood.

Recent Advances: It has been demonstrated that IR can alter miRNA expression profiles, varying greatly from one cell type to the next. It is possible that this variation contributes to the range of tumor cell responsiveness that is observed after radiotherapy, especially considering the extensive role for miRNAs in regulating the DDR. In addition, individual miRNAs or miRNA families have been shown to play a multifaceted role in the DDR, regulating multiple members in a single pathway.

Critical Issues: In this review, we will discuss the effects of radiation on miRNA expression as well as explore the function of miRNAs in regulating the cellular response to radiation-induced damage. We will discuss the importance of miRNA regulation at each stage of the DDR, including signal transduction, DNA damage sensing, cell cycle checkpoint activation, DNA double-strand break repair, and apoptosis. We will focus on emphasizing the importance of a single miRNA targeting several mediators within a pathway.

Future Directions: miRNAs will continue to emerge as critical regulators of the DDR. Understanding the role of miRNAs in the response to IR will provide insights for improving the current standard therapy.

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References

Moskwa P, Buffa F, Pan Y, Panchakshari R, Gottipati P, Muschel R . miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell. 2011; 41(2):210-20. PMC: 3249932. DOI: 10.1016/j.molcel.2010.12.005. View

Willimott S, Wagner S . miR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells. J Biol Chem. 2011; 287(4):2608-17. PMC: 3268420. DOI: 10.1074/jbc.M111.285718. View

Kwon J, Kim B, Kwak S, Bae I, Han Y . Ionizing radiation-inducible microRNA miR-193a-3p induces apoptosis by directly targeting Mcl-1. Apoptosis. 2013; 18(7):896-909. DOI: 10.1007/s10495-013-0841-7. View

Ambs S, Prueitt R, Yi M, Hudson R, Howe T, Petrocca F . Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res. 2008; 68(15):6162-70. PMC: 2597340. DOI: 10.1158/0008-5472.CAN-08-0144. View

Chaudhry M, Omaruddin R . Differential regulation of microRNA expression in irradiated and bystander cells. Mol Biol (Mosk). 2012; 46(4):634-43. View

Butz H, Liko I, Czirjak S, Igaz P, Munayem Khan M, Zivkovic V . Down-regulation of Wee1 kinase by a specific subset of microRNA in human sporadic pituitary adenomas. J Clin Endocrinol Metab. 2010; 95(10):E181-91. DOI: 10.1210/jc.2010-0581. View

Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko Jr R . microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Cancer Res. 2009; 69(20):8157-65. PMC: 2763324. DOI: 10.1158/0008-5472.CAN-09-1996. View

Lok B, Powell S . Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement. Clin Cancer Res. 2012; 18(23):6400-6. PMC: 3513650. DOI: 10.1158/1078-0432.CCR-11-3150. View

Nie J, Liu L, Zheng W, Chen L, Wu X, Xu Y . microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2. Carcinogenesis. 2011; 33(1):220-5. DOI: 10.1093/carcin/bgr245. View

10.

Chaudhry M, Omaruddin R, Brumbaugh C, Tariq M, Pourmand N . Identification of radiation-induced microRNA transcriptome by next-generation massively parallel sequencing. J Radiat Res. 2013; 54(5):808-22. PMC: 3766286. DOI: 10.1093/jrr/rrt014. View

11.

Fang J, Song X, Tian J, Chen H, Li D, Wang J . Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes. Apoptosis. 2011; 17(4):410-23. DOI: 10.1007/s10495-011-0683-0. View

12.

Kan T, Sato F, Ito T, Matsumura N, David S, Cheng Y . The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim. Gastroenterology. 2009; 136(5):1689-700. PMC: 2887605. DOI: 10.1053/j.gastro.2009.02.002. View

13.

Friedman R, Farh K, Burge C, Bartel D . Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2008; 19(1):92-105. PMC: 2612969. DOI: 10.1101/gr.082701.108. View

14.

Joly-Tonetti N, Vinuelas J, Gandrillon O, Lamartine J . Differential miRNA expression profiles in proliferating or differentiated keratinocytes in response to gamma irradiation. BMC Genomics. 2013; 14:184. PMC: 3610249. DOI: 10.1186/1471-2164-14-184. View

15.

Guttilla I, White B . Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J Biol Chem. 2009; 284(35):23204-16. PMC: 2749094. DOI: 10.1074/jbc.M109.031427. View

16.

Sokolov M, Panyutin I, Neumann R . Unraveling the global microRNAome responses to ionizing radiation in human embryonic stem cells. PLoS One. 2012; 7(2):e31028. PMC: 3275573. DOI: 10.1371/journal.pone.0031028. View

17.

Sun F, Fu H, Liu Q, Tie Y, Zhu J, Xing R . Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest. FEBS Lett. 2008; 582(10):1564-8. DOI: 10.1016/j.febslet.2008.03.057. View

18.

Zhang C, Zhang J, Zhang A, Shi Z, Han L, Jia Z . MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma. Mol Cancer. 2010; 9:229. PMC: 2939570. DOI: 10.1186/1476-4598-9-229. View

19.

Ciafre S, Galardi S, Mangiola A, Ferracin M, Liu C, Sabatino G . Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun. 2005; 334(4):1351-8. DOI: 10.1016/j.bbrc.2005.07.030. View

20.

Hirata H, Hinoda Y, Ueno K, Shahryari V, Tabatabai Z, Dahiya R . MicroRNA-1826 targets VEGFC, beta-catenin (CTNNB1) and MEK1 (MAP2K1) in human bladder cancer. Carcinogenesis. 2011; 33(1):41-8. PMC: 3276333. DOI: 10.1093/carcin/bgr239. View