Bone Marrow Mesenchymal Stem Cells Protect Against Retinal Ganglion Cell Loss in Aged Rats with Glaucoma

Overview

Journal Clin Interv Aging

Publisher Dove Medical Press

Specialty Geriatrics

Date 2013 Nov 9

PMID 24204132

Citations 21

Authors

Ying Hu

Hai Bo Tan

Xin Mei Wang

Hua Rong

Hong Ping Cui

Hao Cui

Affiliations

Soon will be listed here.

Abstract

Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma.

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