» Articles » PMID: 24204132

Bone Marrow Mesenchymal Stem Cells Protect Against Retinal Ganglion Cell Loss in Aged Rats with Glaucoma

Overview
Publisher Dove Medical Press
Specialty Geriatrics
Date 2013 Nov 9
PMID 24204132
Citations 21
Authors
Affiliations
Soon will be listed here.
Abstract

Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma.

Citing Articles

Stem Cell-Based Therapies for Glaucoma Treatment: A Review Bridging the Gap in Veterinary Patients.

de Sousa Moreira A, Lopes B, Sousa A, Coelho A, Sousa P, Araujo A Int J Mol Sci. 2025; 26(1.

PMID: 39796087 PMC: 11719664. DOI: 10.3390/ijms26010232.


Small extracellular vesicles derived from microRNA-22-3p-overexpressing mesenchymal stem cells protect retinal ganglion cells by regulating MAPK pathway.

Yu B, Wang K, Hao H, Liu Y, Yue Y, Li X Commun Biol. 2024; 7(1):807.

PMID: 38961177 PMC: 11222527. DOI: 10.1038/s42003-024-06511-z.


ADSC-Exos outperform BMSC-Exos in alleviating hydrostatic pressure-induced injury to retinal ganglion cells by upregulating nerve growth factors.

Zheng Z, Kong L, Dai M, Chen Y, Chen Y World J Stem Cells. 2024; 15(12):1077-1092.

PMID: 38179214 PMC: 10762527. DOI: 10.4252/wjsc.v15.i12.1077.


Advances in cell therapies using stem cells/progenitors as a novel approach for neurovascular repair of the diabetic retina.

Lechner J, Medina R, Lois N, Stitt A Stem Cell Res Ther. 2022; 13(1):388.

PMID: 35907890 PMC: 9338609. DOI: 10.1186/s13287-022-03073-x.


Evaluation of neuroprotective and immunomodulatory properties of mesenchymal stem cells in an ex vivo retinal explant model.

Reboussin E, Buffault J, Brignole-Baudouin F, Reaux-Le Goazigo A, Riancho L, Olmiere C J Neuroinflammation. 2022; 19(1):63.

PMID: 35236378 PMC: 8892697. DOI: 10.1186/s12974-022-02418-w.


References
1.
Bouhenni R, Dunmire J, Sewell A, Edward D . Animal models of glaucoma. J Biomed Biotechnol. 2012; 2012:692609. PMC: 3364028. DOI: 10.1155/2012/692609. View

2.
Jindal N, Mukhopadhyay A, Anand A . The emerging role of stem cells in ocular neurodegeneration: hype or hope?. Mol Cell Biochem. 2012; 365(1-2):65-76. DOI: 10.1007/s11010-012-1244-8. View

3.
Balaggan K, Ali R . Ocular gene delivery using lentiviral vectors. Gene Ther. 2011; 19(2):145-53. DOI: 10.1038/gt.2011.153. View

4.
Chrysostomou V, Rezania F, Trounce I, Crowston J . Oxidative stress and mitochondrial dysfunction in glaucoma. Curr Opin Pharmacol. 2012; 13(1):12-5. DOI: 10.1016/j.coph.2012.09.008. View

5.
Wilson A, Di Polo A . Gene therapy for retinal ganglion cell neuroprotection in glaucoma. Gene Ther. 2011; 19(2):127-36. DOI: 10.1038/gt.2011.142. View