Skin Wound Healing and Scarring: Fetal Wounds and Regenerative Restitution

Overview

Journal Birth Defects Res C Embryo Today

Date 2013 Nov 9

PMID 24203921

Citations 60

Authors

Cecelia C Yates

Patricia Hebda

Alan Wells

Affiliations

Soon will be listed here.

Abstract

The adverse physiological and psychological effects of scars formation after healing of wounds are broad and a major medical problem for patients. In utero, fetal wounds heal in a regenerative manner, though the mechanisms are unknown. Differences in fetal scarless regeneration and adult repair can provide key insight into reduction of scarring therapy. Understanding the cellular and extracellular matrix alterations in excessive adult scarring in comparison to fetal scarless healing may have important implications. Herein, we propose that matrix can be controlled via cellular therapy to resemble a fetal-like matrix that will result in reduced scarring.

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