Pd(0)-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged As a PET Tracer

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2013 Nov 8

PMID 24196412

Citations 2

Authors

Damien James

Jean-Marc Escudier

Magali Szlosek-Pinaud

Eric Fouquet

Affiliations

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Abstract

The methyl transfer reaction from activated monomethyltin, via a modified Stille coupling reaction, was studied under "ligandless" conditions on fully deprotected 5'-modified nucleosides and one dinucleotide. The reaction was optimized to proceed in a few minutes and quantitative yield, even under dilute conditions, thus affording a rapid and efficient new method for oligonucleotide labelling with carbon-11.

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