Impact of Surgical Extent and Sex on the Hepatic Metastasis of Colon Cancer

Overview

Journal Surg Today

Specialty General Surgery

Date 2013 Nov 6

PMID 24190423

Citations 11

Authors

Liat Sorski

Ben Levi

Lee Shaashua

Elad Neeman

Marganit Benish

Pini Matzner

Aviad Hoffman

Shamgar Ben-Eliyahu

Affiliations

Soon will be listed here.

Abstract

Purpose: Extensive oncological surgeries were previously suggested to increase cancer recurrence rates. We herein studied the impact of different surgical procedures and sex on colorectal cancer liver metastasis, employing several tumor inoculation approaches in BALB/c mice.

Methods: Experimental hepatic metastases of the syngeneic CT26 colorectal cancer line were induced either by intra-portal inoculation or intra-splenic inoculation, employing different tumor loads. Following intra-splenic inoculation, the entire spleen or an injected hemi-spleen was removed. Additionally, the magnitude of the surgical trauma accompanying the injection procedure was manipulated.

Results: Increasing the surgical trauma by adding laparotomy or extending the length of the surgery and hypothermia did not significantly affect the number of liver metastases or liver weight for any of the injection methods and tumor loads. The development of metastasis was significantly greater in males than in females under all conditions studied--a difference not explained by the direct effects of sex hormones on in vitro CT26 proliferation or vitality.

Conclusion: Concurring with less controlled clinical observations, the surgical extensiveness did not significantly affect CT26 hepatic metastasis, potentially due to a ceiling effect of the surgical trauma on the metastatic process. The sexual dimorphism observed for the CT26 metastasis should be investigated in the context of surgical stress and considering anti-CT26 immunoreactivity.

Citing Articles

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Liver imaging features by convolutional neural network to predict the metachronous liver metastasis in stage I-III colorectal cancer patients based on preoperative abdominal CT scan.

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Prevention of liver metastases through perioperative acute CpG-C immune stimulation.

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