Retrospective Study of Neuroblastoma in Chinese Neonates from 1994 to 2011: an Evaluation of Diagnosis, Treatments, and Prognosis : a 10-year Restrospective Study of Neonatal Neuroblastoma

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 2013 Nov 6

PMID 24189916

Authors

Yaodong Zhou

Kai Li

Shan Zheng

Lian Chen

Affiliations

Soon will be listed here.

Abstract

Purpose: The purpose of the study is to review the clinical features, treatments, and outcomes of neonatal neuroblastoma (NB).

Methods: A retrospective analysis was performed on 42 patients with NB between January 1994 and December 2011.

Results: MYCN amplification was detected in nine tumor samples. The ratio of unfavorable histology to favorable histology was 1:2 in NB patients. The 5-year overall survival (OS) of NB patients was 85.7 %. The 5-year OS in patients in the operation group was 83.3 %, chemotherapy group was 83.3 %, and the "wait-and-see" group was 100 % (P = 0.04). Overall, the prognosis was favorable, except in patients with elevated MYCN amplification or vanillylmandelic acid.

Conclusions: NB patients were more sensitive and vulnerable to chemotherapy and operation. The "wait-and-see" strategy should be highlighted in the treatment of NB.

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