Plasma Membrane Guanylate Cyclase is a Multimodule Transduction System

Overview

Journal Amino Acids

Specialty Biochemistry

Date 2013 Nov 5

PMID 24186045

Citations 6

Authors

R K Sharma

T Duda

A Sitaramayya

Affiliations

Soon will be listed here.

Abstract

This minireview highlights the studies which suggest that guanylate cyclase is a single-component transducing system, containing distinct signaling modules in a single membrane-spanning protein. A guanylate cyclase signaling model is proposed which envisions the following sequential events: (1) a signal is initiated by the binding of the hormone to the ligand binding module; (2) the signal is potentiated by ATP at ARM; and (3) the amplified signal is finally transduced at the catalytic site. All of these signaling steps together constitute a switch, which when turned on, generates the second messenger cyclic GMP.

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Three dimensional atomic model and experimental validation for the ATP-Regulated Module (ARM) of the atrial natriuretic factor receptor guanylate cyclase.

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Three dimensional atomic model and experimental validation for the ATP-Regulated Module (ARM) of the atrial natriuretic factor receptor guanylate cyclase.

Duda T, Yadav P, Jankowska A, Venkataraman V, Sharma R Mol Cell Biochem. 2001; 214(1-2):7-14.

PMID: 11195792 DOI: 10.1023/a:1007144328682.

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