Trace Elements in Diabetes Mellitus

Overview

Journal J Clin Diagn Res

Specialty General Medicine

Date 2013 Nov 2

PMID 24179883

Citations 24

Authors

Praveeena S

Sujatha Pasula

K Sameera

Affiliations

Soon will be listed here.

Abstract

Introduction: Diabetes Mellitus is the commonest major metabolic disease and most prevalent diseases worldwide.Its related morbidity is due to its micro and macro angiopathic complications.

Aim: The aim of this study was to measure and compare the serum levels of zinc and magnesium in normal individuals and in diabetic patients.

Method: Analysis of minerals was done in plasma by using a Varian Spectra AA 220 model atomic absorption spectrophotometer.

Result: Our observations showed a definite lowering of serum magnesium (p<0.001) and serum zinc levels (p<0.001) were significant in diabetic group.

Conclusion: The cause of diabetic hypomagnesaemia is multifactorial. An altered metabolism, a poor glycaemic control and osmotic diuresis may be contributory factors. Decreased serum zinc levels in diabetes may be caused by an increase in urinary loss. These decreased levels of trace elements cause disturbances in glucose transport across cell membrane lead to insufficient formation and secretion of insulin by pancreas which compromise in the antioxidant defense mechanisms.

Citing Articles

Essential Oils: Chemistry and Pharmacological Activities-Part II.

de Sousa D, de Assis Oliveira F, Arcanjo D, Fonseca D, Duarte A, de Oliveira Barbosa C Biomedicines. 2024; 12(6).

PMID: 38927394 PMC: 11200837. DOI: 10.3390/biomedicines12061185.

Diabetic Neuropathy of the Retina and Inflammation: Perspectives.

Bikbova G, Oshitari T, Bikbov M Int J Mol Sci. 2023; 24(11).

PMID: 37298118 PMC: 10252894. DOI: 10.3390/ijms24119166.

The effect of different ammonium to nitrate ratios on antioxidant activity, morpho-physiological and phytochemical traits of Moldavian balm (Dracocephalum moldavica).

Naseri A, Alirezalu A, Noruzi P, Alirezalu K Sci Rep. 2022; 12(1):16841.

PMID: 36207586 PMC: 9546921. DOI: 10.1038/s41598-022-21338-6.

No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes.

Dziedzic E, Gasior J, Tuzimek A, Paleczny J, Kwasny M, Dabrowski M Biomolecules. 2022; 12(7).

PMID: 35883417 PMC: 9313242. DOI: 10.3390/biom12070862.

Pilot Study of Trace Elements in the Infusion of Medicinal Plants Used for Diabetes Treatment.

Brima E, Siddeeg S Int J Anal Chem. 2022; 2022:3021396.

PMID: 35478694 PMC: 9038423. DOI: 10.1155/2022/3021396.

References

Vincent J . Quest for the molecular mechanism of chromium action and its relationship to diabetes. Nutr Rev. 2000; 58(3 Pt 1):67-72. DOI: 10.1111/j.1753-4887.2000.tb01841.x. View

Santoro D, Natali A, Palombo C, Brandi L, Piatti M, Ghione S . Effects of chronic angiotensin converting enzyme inhibition on glucose tolerance and insulin sensitivity in essential hypertension. Hypertension. 1992; 20(2):181-91. DOI: 10.1161/01.hyp.20.2.181. View

Zargar A, Shah N, Masoodi S, Laway B, Dar F, Khan A . Copper, zinc, and magnesium levels in non-insulin dependent diabetes mellitus. Postgrad Med J. 1999; 74(877):665-8. PMC: 2431594. DOI: 10.1136/pgmj.74.877.665. View

Worcester E, Coe F . New insights into the pathogenesis of idiopathic hypercalciuria. Semin Nephrol. 2008; 28(2):120-32. PMC: 2362396. DOI: 10.1016/j.semnephrol.2008.01.005. View

Resnick L, Gupta R, Bhargava K, Gruenspan H, Alderman M, LARAGH J . Cellular ions in hypertension, diabetes, and obesity. A nuclear magnetic resonance spectroscopic study. Hypertension. 1991; 17(6 Pt 2):951-7. DOI: 10.1161/01.hyp.17.6.951. View

Kowluru R, Kennedy A . Therapeutic potential of anti-oxidants and diabetic retinopathy. Expert Opin Investig Drugs. 2002; 10(9):1665-76. DOI: 10.1517/13543784.10.9.1665. View

LINDEMAN R, Adler S, YIENGST M, Beard E . Influence of various nutrients on urinary divalent cation excretion. J Lab Clin Med. 1967; 70(2):236-45. View

Grafton G, Baxter M . The role of magnesium in diabetes mellitus. A possible mechanism for the development of diabetic complications. J Diabetes Complications. 1992; 6(2):143-9. DOI: 10.1016/1056-8727(92)90026-h. View

Yajnik C, Smith R, Hockaday T, Ward N . Fasting plasma magnesium concentrations and glucose disposal in diabetes. Br Med J (Clin Res Ed). 1984; 288(6423):1032-4. PMC: 1442636. DOI: 10.1136/bmj.288.6423.1032. View

10.

Cahill Jr G, Etzwiler L, Freinkel N . Editorial: "Control" and diabetes. N Engl J Med. 1976; 294(18):1004-5. DOI: 10.1056/NEJM197604292941811. View

11.

Nielsen F . New essential trace elements for the life sciences. Biol Trace Elem Res. 1990; 26-27:599-611. View

12.

Nerlich A, Sauer U, Wagner E, Koch M, Schleicher E . Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes. Diabetes. 1998; 47(2):170-8. DOI: 10.2337/diab.47.2.170. View

13.

Chausmer A . Zinc, insulin and diabetes. J Am Coll Nutr. 1998; 17(2):109-15. DOI: 10.1080/07315724.1998.10718735. View

14.

Rukgauer M . Trace elements in diabetes mellitus. Peculiarities and clinical validity of determinations in blood cells. J Trace Elem Med Biol. 2000; 14(1):21-7. DOI: 10.1016/S0946-672X(00)80019-X. View

15.

Kareem I, Jaweed S, Bardapurkar J, Patil V . Study of magnesium, glycosylated hemoglobin and lipid profile in diabetic retinopathy. Indian J Clin Biochem. 2012; 19(2):124-7. PMC: 3454207. DOI: 10.1007/BF02894270. View

16.

Mocchegiani E, Boemi M, Fumelli P, Fabris N . Zinc-dependent low thymic hormone level in type I diabetes. Diabetes. 1989; 38(7):932-7. DOI: 10.2337/diab.38.7.932. View

17.

Hashemipour M, Kelishadi R, Shapouri J, Sarrafzadegan N, Amini M, Tavakoli N . Effect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese children. Hormones (Athens). 2010; 8(4):279-85. DOI: 10.14310/horm.2002.1244. View

18.

Viktorinova A, Toserova E, Krizko M, Durackova Z . Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus. Metabolism. 2009; 58(10):1477-82. DOI: 10.1016/j.metabol.2009.04.035. View

19.

Seyoum B, Siraj E, Saenz C, Abdulkadir J . Hypomagnesemia in Ethiopians with diabetes mellitus. Ethn Dis. 2008; 18(2):147-51. View

20.

Walti M, Zimmermann M, Spinas G, Hurrell R . Low plasma magnesium in type 2 diabetes. Swiss Med Wkly. 2003; 133(19-20):289-92. DOI: 10.4414/smw.2003.10170. View