Disturbed Resting State EEG Synchronization in Bipolar Disorder: A Graph-theoretic Analysis

Overview

Journal Neuroimage Clin

Publisher Elsevier

Specialties Neurology
Radiology

Date 2013 Nov 2

PMID 24179795

Citations 52

Authors

Dae-Jin Kim

Amanda R Bolbecker

Josselyn Howell

Olga Rass

Olaf Sporns

William P Hetrick

Alan Breier

Brian F ODonnell

Affiliations

Soon will be listed here.

Abstract

Disruption of functional connectivity may be a key feature of bipolar disorder (BD) which reflects disturbances of synchronization and oscillations within brain networks. We investigated whether the resting electroencephalogram (EEG) in patients with BD showed altered synchronization or network properties. Resting-state EEG was recorded in 57 BD type-I patients and 87 healthy control subjects. Functional connectivity between pairs of EEG channels was measured using synchronization likelihood (SL) for 5 frequency bands (δ, θ, α, β, and γ). Graph-theoretic analysis was applied to SL over the electrode array to assess network properties. BD patients showed a decrease of mean synchronization in the alpha band, and the decreases were greatest in fronto-central and centro-parietal connections. In addition, the clustering coefficient and global efficiency were decreased in BD patients, whereas the characteristic path length increased. We also found that the normalized characteristic path length and small-worldness were significantly correlated with depression scores in BD patients. These results suggest that BD patients show impaired neural synchronization at rest and a disruption of resting-state functional connectivity.

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References

Calhoun V, Sui J, Kiehl K, Turner J, Allen E, Pearlson G . Exploring the psychosis functional connectome: aberrant intrinsic networks in schizophrenia and bipolar disorder. Front Psychiatry. 2012; 2:75. PMC: 3254121. DOI: 10.3389/fpsyt.2011.00075. View

Whittington M . Can brain rhythms inform on underlying pathology in schizophrenia?. Biol Psychiatry. 2008; 63(8):728-9. DOI: 10.1016/j.biopsych.2008.02.007. View

Montez T, Linkenkaer-Hansen K, van Dijk B, Stam C . Synchronization likelihood with explicit time-frequency priors. Neuroimage. 2006; 33(4):1117-25. DOI: 10.1016/j.neuroimage.2006.06.066. View

Zubieta J, Huguelet P, Ohl L, Koeppe R, Kilbourn M, Carr J . High vesicular monoamine transporter binding in asymptomatic bipolar I disorder: sex differences and cognitive correlates. Am J Psychiatry. 2000; 157(10):1619-28. DOI: 10.1176/appi.ajp.157.10.1619. View

Benes F, Todtenkopf M, Logiotatos P, Williams M . Glutamate decarboxylase(65)-immunoreactive terminals in cingulate and prefrontal cortices of schizophrenic and bipolar brain. J Chem Neuroanat. 2001; 20(3-4):259-69. DOI: 10.1016/s0891-0618(00)00105-8. View

Petty F . GABA and mood disorders: a brief review and hypothesis. J Affect Disord. 1995; 34(4):275-81. DOI: 10.1016/0165-0327(95)00025-i. View

Lynall M, Bassett D, Kerwin R, McKenna P, Kitzbichler M, Muller U . Functional connectivity and brain networks in schizophrenia. J Neurosci. 2010; 30(28):9477-87. PMC: 2914251. DOI: 10.1523/JNEUROSCI.0333-10.2010. View

Pereda E, Quian Quiroga R, Bhattacharya J . Nonlinear multivariate analysis of neurophysiological signals. Prog Neurobiol. 2005; 77(1-2):1-37. DOI: 10.1016/j.pneurobio.2005.10.003. View

Fingelkurts A, Fingelkurts A, Kivisaari R, Pekkonen E, Ilmoniemi R, Kahkonen S . Local and remote functional connectivity of neocortex under the inhibition influence. Neuroimage. 2004; 22(3):1390-406. DOI: 10.1016/j.neuroimage.2004.03.013. View

10.

Schoonheim M, Geurts J, Landi D, Douw L, van der Meer M, Vrenken H . Functional connectivity changes in multiple sclerosis patients: a graph analytical study of MEG resting state data. Hum Brain Mapp. 2011; 34(1):52-61. PMC: 6870283. DOI: 10.1002/hbm.21424. View

11.

Wang L, Metzak P, Honer W, Woodward T . Impaired efficiency of functional networks underlying episodic memory-for-context in schizophrenia. J Neurosci. 2010; 30(39):13171-9. PMC: 6633526. DOI: 10.1523/JNEUROSCI.3514-10.2010. View

12.

Watts D, Strogatz S . Collective dynamics of 'small-world' networks. Nature. 1998; 393(6684):440-2. DOI: 10.1038/30918. View

13.

Doesburg S, Kitajo K, Ward L . Increased gamma-band synchrony precedes switching of conscious perceptual objects in binocular rivalry. Neuroreport. 2005; 16(11):1139-42. DOI: 10.1097/00001756-200508010-00001. View

14.

Stam C, de Haan W, Daffertshofer A, Jones B, Manshanden I, Van Cappellen van Walsum A . Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease. Brain. 2008; 132(Pt 1):213-24. DOI: 10.1093/brain/awn262. View

15.

Belmaker R . Bipolar disorder. N Engl J Med. 2004; 351(5):476-86. DOI: 10.1056/NEJMra035354. View

16.

Newman M . Finding community structure in networks using the eigenvectors of matrices. Phys Rev E Stat Nonlin Soft Matter Phys. 2006; 74(3 Pt 2):036104. DOI: 10.1103/PhysRevE.74.036104. View

17.

van Wijk B, Stam C, Daffertshofer A . Comparing brain networks of different size and connectivity density using graph theory. PLoS One. 2010; 5(10):e13701. PMC: 2965659. DOI: 10.1371/journal.pone.0013701. View

18.

Vederine F, Wessa M, Leboyer M, Houenou J . A meta-analysis of whole-brain diffusion tensor imaging studies in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2011; 35(8):1820-6. DOI: 10.1016/j.pnpbp.2011.05.009. View

19.

Uhlhaas P, Singer W . Abnormal neural oscillations and synchrony in schizophrenia. Nat Rev Neurosci. 2010; 11(2):100-13. DOI: 10.1038/nrn2774. View

20.

Nunez P, Silberstein R, Shi Z, Carpenter M, Srinivasan R, Tucker D . EEG coherency II: experimental comparisons of multiple measures. Clin Neurophysiol. 1999; 110(3):469-86. DOI: 10.1016/s1388-2457(98)00043-1. View