Cation Selectivity of the Resting Membrane of Squid Axon

Overview

Journal J Membr Biol

Date 2013 Nov 2

PMID 24177659

Citations 3

Authors

S Hagiwara

D C Eaton

A E Stuart

N P Rosenthal

Affiliations

Soon will be listed here.

Abstract

Permeability constant ratios among monovalent cations were studied in the resting membrane of a giant axon of a Pacific squid,Loligo opalescens, by observing the relationship between the membrane potential and the ion concentration.The average permeability ratios are: Tl, 1.8; K, 1.0; Rb, 0.72; Cs, 0.16; Na, <0.08; Li, <0.08. These permeability ratios suggest that neither valinomycin nor nonactin are adequate models for the sites producing the resting permeability in the axonal membrane.Cyclic polyetherbis(t-butyl cyclohexyl) 18-crown-6 does not increase the permeability ratioP Cs/P K except when applied at concentrations (5×10(-5) M) at which the surfactant properties of this molecule may become significant.

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References

HODGKIN A, Horowicz P . The influence of potassium and chloride ions on the membrane potential of single muscle fibres. J Physiol. 1959; 148:127-60. PMC: 1363113. DOI: 10.1113/jphysiol.1959.sp006278. View

Finkelstein A, Cass A . Permeability and electrical properties of thin lipid membranes. J Gen Physiol. 1968; 52(1):145Suppl+. View

BINSTOCK L, Lecar H . Ammonium ion currents in the squid giant axon. J Gen Physiol. 1969; 53(3):342-61. PMC: 2202909. DOI: 10.1085/jgp.53.3.342. View

Sjodin R . Rubidium and cesium fluxes in muscle as related to the membrane potential. J Gen Physiol. 1959; 42(5):983-1003. PMC: 2194939. DOI: 10.1085/jgp.42.5.983. View

HODGKIN A, Katz B . The effect of sodium ions on the electrical activity of giant axon of the squid. J Physiol. 1949; 108(1):37-77. PMC: 1392331. DOI: 10.1113/jphysiol.1949.sp004310. View

Eisenman G . THE INFLUENCE OF NA, K LI, RB, AND CS ON CELLULAR POTENTIALS AND RELATED PHENOMENA. Bol Inst Estud Med Biol Univ Nac Auton Mex. 1963; 21:155-83. View

Adelman Jr W, FOK Y . INTERNALLY PERFUSED SQUID AXONS STUDIED UNDER VOLTAGE CLAMP CONDITIONS. II. RESULTS. THE EFFECTS OF INTERNAL POTASSIUM AND SODIUM ON MEMBRANE ELECTRICAL CHARACTERISTICS. J Cell Comp Physiol. 1964; 64:429-43. DOI: 10.1002/jcp.1030640315. View

Hagiwara S, Toyama K, Hayashi H . Mechanisms of anion and cation permeations in the resting membrane of a barnacle muscle fiber. J Gen Physiol. 1971; 57(4):408-34. PMC: 2203109. DOI: 10.1085/jgp.57.4.408. View

Baker P, HODGKIN A, Shaw T . The effects of changes in internal ionic concentrations on the electrical properties of perfused giant axons. J Physiol. 1962; 164:355-74. PMC: 1359309. DOI: 10.1113/jphysiol.1962.sp007026. View

10.

Eisenman G, Ciani S, Szabo G . Some theoretically expected and experimentally observed properties of lipid bilayer membranes containing neutral molecular carriers of ions. Fed Proc. 1968; 27(6):1289-304. View

11.

Stillman I, Gilbert D, Robbins M . Monactin does not influence potassium permeability in the squid axonal membrane. Biochim Biophys Acta. 1970; 203(2):338-41. DOI: 10.1016/0005-2736(70)90149-5. View

12.

Baker P, HODGKIN A, MEVES H . THE EFFECT OF DILUTING THE INTERNAL SOLUTION ON THE ELECTRICAL PROPERTIES OF A PERFUSED GIANT AXON. J Physiol. 1964; 170:541-60. PMC: 1368689. DOI: 10.1113/jphysiol.1964.sp007348. View