Clinical Neurogenetics: Amyotrophic Lateral Sclerosis

Overview

Journal Neurol Clin

Specialty Neurology

Date 2013 Nov 2

PMID 24176417

Citations 16

Authors

Matthew B Harms

Robert H Baloh

Affiliations

Soon will be listed here.

Abstract

Our understanding of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, is expanding rapidly as its genetic causes are uncovered. The pace of new gene discovery over the last 5 years has accelerated, providing new insights into the pathogenesis of disease and highlighting biological pathways as targets for therapeutic development. This article reviews our current understanding of the heritability of ALS and provides an overview of each of the major ALS genes, highlighting their phenotypic characteristics and frequencies as a guide for clinicians evaluating patients with ALS.

Citing Articles

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Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial.

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